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Lewy bodies in progressive supranuclear palsy.
Acta Neuropathol. 2002 Sep; 104(3):273-8.AN

Abstract

Lewy bodies (LBs), whose major component is alpha-synuclein, are a pathological hallmark of Parkinson's disease (PD) but have rarely been reported in progressive supranuclear palsy (PSP). Whether LBs in PSP represent the aging process or the coexistence of PD remains unclear. We found LBs in 5 of 16 patients with PSP. In 4 patients LBs were distributed widely throughout the brain stem and cerebrum in a pattern similar to that in PD. In the remaining patient one LB was found in the pontine reticular formation. Semiquantitative analysis showed that neuronal loss in the locus coeruleus and the dorsal vagal nucleus was more severe in patients with LBs than in patients without LBs. Double-labeling immunohistochemical studies showed co-localization of alpha-synuclein and tau in some neurons. Our study suggests that patients who have PSP with LBs constitute a subset of patients with PSP in whom Lewy body disease is also present.

Authors+Show Affiliations

Department of Neurology, Juntendo University Scvhool of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. h_mori@med.juntendo.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12172913

Citation

Mori, Hideo, et al. "Lewy Bodies in Progressive Supranuclear Palsy." Acta Neuropathologica, vol. 104, no. 3, 2002, pp. 273-8.
Mori H, Oda M, Komori T, et al. Lewy bodies in progressive supranuclear palsy. Acta Neuropathol. 2002;104(3):273-8.
Mori, H., Oda, M., Komori, T., Arai, N., Takanashi, M., Mizutani, T., Hirai, S., & Mizuno, Y. (2002). Lewy bodies in progressive supranuclear palsy. Acta Neuropathologica, 104(3), 273-8.
Mori H, et al. Lewy Bodies in Progressive Supranuclear Palsy. Acta Neuropathol. 2002;104(3):273-8. PubMed PMID: 12172913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lewy bodies in progressive supranuclear palsy. AU - Mori,Hideo, AU - Oda,Masaya, AU - Komori,Takashi, AU - Arai,Nobutaka, AU - Takanashi,Masashi, AU - Mizutani,Toshio, AU - Hirai,Shunnichi, AU - Mizuno,Yosikuni, Y1 - 2002/05/04/ PY - 2001/10/29/received PY - 2002/02/11/revised PY - 2002/02/11/accepted PY - 2002/8/13/pubmed PY - 2002/10/18/medline PY - 2002/8/13/entrez SP - 273 EP - 8 JF - Acta neuropathologica JO - Acta Neuropathol VL - 104 IS - 3 N2 - Lewy bodies (LBs), whose major component is alpha-synuclein, are a pathological hallmark of Parkinson's disease (PD) but have rarely been reported in progressive supranuclear palsy (PSP). Whether LBs in PSP represent the aging process or the coexistence of PD remains unclear. We found LBs in 5 of 16 patients with PSP. In 4 patients LBs were distributed widely throughout the brain stem and cerebrum in a pattern similar to that in PD. In the remaining patient one LB was found in the pontine reticular formation. Semiquantitative analysis showed that neuronal loss in the locus coeruleus and the dorsal vagal nucleus was more severe in patients with LBs than in patients without LBs. Double-labeling immunohistochemical studies showed co-localization of alpha-synuclein and tau in some neurons. Our study suggests that patients who have PSP with LBs constitute a subset of patients with PSP in whom Lewy body disease is also present. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/12172913/Lewy_bodies_in_progressive_supranuclear_palsy_ L2 - https://dx.doi.org/10.1007/s00401-002-0555-3 DB - PRIME DP - Unbound Medicine ER -