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Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation.

Abstract

OBJECTIVE

To examine the effect of methotrexate (MTX) and folic acid supplementation on the homocysteine level in patients with rheumatoid arthritis (RA).

METHODS

A cross sectional study was performed in 81 patients with RA, comprising a standardized clinical interview, an examination, and a blood specimen test.

RESULTS

P-homocysteine tended to be lower in 41 patients receiving MTX, compared with 40 patients not receiving MTX. Of the MTX treated patients, 76% received folic acid supplementation. Multivariate analysis revealed a statistically significant association between P-homocysteine and P-creatinine (p < 0.001), and disease activity/progression measured by the Health Assessment Questionnaire score (p < 0.001). There was a tendency to negative association between P-homocys-teine and folic acid supplementation.

CONCLUSION

P-homocysteine in patients with RA receiving MTX and folic acid supplementation did not differ significantly from P-homocysteine in RA patients receiving other types of treatment.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Rheumatology, University Hospital of Aalborg, Denmark.

    , , , , ,

    Source

    The Journal of rheumatology 29:8 2002 Aug pg 1615-8

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Antirheumatic Agents
    Arthritis, Rheumatoid
    Disability Evaluation
    Drug Therapy, Combination
    Female
    Folic Acid
    Folic Acid Antagonists
    Folic Acid Deficiency
    Health Status
    Homocysteine
    Humans
    Hyperhomocysteinemia
    Male
    Methotrexate
    Middle Aged
    Surveys and Questionnaires
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12180718

    Citation

    Jensen, Ole Kudsk, et al. "Hyperhomocysteinemia in Rheumatoid Arthritis: Influence of Methotrexate Treatment and Folic Acid Supplementation." The Journal of Rheumatology, vol. 29, no. 8, 2002, pp. 1615-8.
    Jensen OK, Rasmussen C, Mollerup F, et al. Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation. J Rheumatol. 2002;29(8):1615-8.
    Jensen, O. K., Rasmussen, C., Mollerup, F., Christensen, P. B., Hansen, H., Ekelund, S., & Thulstrup, A. M. (2002). Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation. The Journal of Rheumatology, 29(8), pp. 1615-8.
    Jensen OK, et al. Hyperhomocysteinemia in Rheumatoid Arthritis: Influence of Methotrexate Treatment and Folic Acid Supplementation. J Rheumatol. 2002;29(8):1615-8. PubMed PMID: 12180718.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation. AU - Jensen,Ole Kudsk, AU - Rasmussen,Claus, AU - Mollerup,Frank, AU - Christensen,Peder Bjerg, AU - Hansen,Henrik, AU - Ekelund,Suzanne, AU - Thulstrup,Ane Marie, PY - 2002/8/16/pubmed PY - 2003/3/19/medline PY - 2002/8/16/entrez SP - 1615 EP - 8 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 29 IS - 8 N2 - OBJECTIVE: To examine the effect of methotrexate (MTX) and folic acid supplementation on the homocysteine level in patients with rheumatoid arthritis (RA). METHODS: A cross sectional study was performed in 81 patients with RA, comprising a standardized clinical interview, an examination, and a blood specimen test. RESULTS: P-homocysteine tended to be lower in 41 patients receiving MTX, compared with 40 patients not receiving MTX. Of the MTX treated patients, 76% received folic acid supplementation. Multivariate analysis revealed a statistically significant association between P-homocysteine and P-creatinine (p < 0.001), and disease activity/progression measured by the Health Assessment Questionnaire score (p < 0.001). There was a tendency to negative association between P-homocys-teine and folic acid supplementation. CONCLUSION: P-homocysteine in patients with RA receiving MTX and folic acid supplementation did not differ significantly from P-homocysteine in RA patients receiving other types of treatment. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/12180718/Hyperhomocysteinemia_in_rheumatoid_arthritis:_influence_of_methotrexate_treatment_and_folic_acid_supplementation_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=12180718 DB - PRIME DP - Unbound Medicine ER -