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Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects.
Obes Res. 2002 Aug; 10(8):717-25.OR

Abstract

OBJECTIVE

The aim of our study was to examine whether plasminogen activator inhibitor-1 (PAI-1) plasma levels varied as a function of differences in glucose tolerance status independently of body fatness, body-fat distribution, and insulin sensitivity.

RESEARCH METHODS AND PROCEDURES

Plasma PAI-1 antigen levels, along with insulin resistance [measured by homeostatic model assessment (HOMA(IR))], central fat accumulation, body composition, blood pressure, and fasting concentrations of glucose, insulin, and lipids, were measured in 229 overweight and obese [body mass index (BMI) > or =25 kg/m(2)) subjects with normal glucose tolerance (NGT) and in 44 age- and BMI-matched subjects with impaired glucose tolerance (IGT).

RESULTS

Plasma PAI-1 antigen levels were significantly higher in IGT than in NGT subjects. Log PAI-1 was positively correlated with BMI, HOMA(IR), and log insulin, and inversely associated with high-density lipoprotein-cholesterol both in IGT and in NGT individuals. On the other hand, log PAI-1 was positively correlated with waist circumference, fat mass (FM), fat-free mass, systolic and diastolic blood pressure, and log triglycerides only in the NGT group. After multivariate analyses, the strongest determinants of PAI-1 levels were BMI, FM, waist circumference, and high-density lipoprotein cholesterol in the NGT group and only HOMA(IR) in the IGT cohort.

DISCUSSION

This study demonstrates that PAI-1 concentrations are higher in IGT than in NGT subjects. Furthermore, we suggest that the influences of total adiposity, central fat, and insulin resistance, main determinants of PAI-1 concentrations, are different according to the degree of glucose tolerance.

Authors+Show Affiliations

Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Transplant, University of Bari, Bari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12181379

Citation

Pannacciulli, Nicola, et al. "Effect of Glucose Tolerance Status On PAI-1 Plasma Levels in Overweight and Obese Subjects." Obesity Research, vol. 10, no. 8, 2002, pp. 717-25.
Pannacciulli N, De Mitrio V, Marino R, et al. Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects. Obes Res. 2002;10(8):717-25.
Pannacciulli, N., De Mitrio, V., Marino, R., Giorgino, R., & De Pergola, G. (2002). Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects. Obesity Research, 10(8), 717-25.
Pannacciulli N, et al. Effect of Glucose Tolerance Status On PAI-1 Plasma Levels in Overweight and Obese Subjects. Obes Res. 2002;10(8):717-25. PubMed PMID: 12181379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects. AU - Pannacciulli,Nicola, AU - De Mitrio,Vito, AU - Marino,Renato, AU - Giorgino,Riccardo, AU - De Pergola,Giovanni, PY - 2002/8/16/pubmed PY - 2003/1/31/medline PY - 2002/8/16/entrez SP - 717 EP - 25 JF - Obesity research JO - Obes Res VL - 10 IS - 8 N2 - OBJECTIVE: The aim of our study was to examine whether plasminogen activator inhibitor-1 (PAI-1) plasma levels varied as a function of differences in glucose tolerance status independently of body fatness, body-fat distribution, and insulin sensitivity. RESEARCH METHODS AND PROCEDURES: Plasma PAI-1 antigen levels, along with insulin resistance [measured by homeostatic model assessment (HOMA(IR))], central fat accumulation, body composition, blood pressure, and fasting concentrations of glucose, insulin, and lipids, were measured in 229 overweight and obese [body mass index (BMI) > or =25 kg/m(2)) subjects with normal glucose tolerance (NGT) and in 44 age- and BMI-matched subjects with impaired glucose tolerance (IGT). RESULTS: Plasma PAI-1 antigen levels were significantly higher in IGT than in NGT subjects. Log PAI-1 was positively correlated with BMI, HOMA(IR), and log insulin, and inversely associated with high-density lipoprotein-cholesterol both in IGT and in NGT individuals. On the other hand, log PAI-1 was positively correlated with waist circumference, fat mass (FM), fat-free mass, systolic and diastolic blood pressure, and log triglycerides only in the NGT group. After multivariate analyses, the strongest determinants of PAI-1 levels were BMI, FM, waist circumference, and high-density lipoprotein cholesterol in the NGT group and only HOMA(IR) in the IGT cohort. DISCUSSION: This study demonstrates that PAI-1 concentrations are higher in IGT than in NGT subjects. Furthermore, we suggest that the influences of total adiposity, central fat, and insulin resistance, main determinants of PAI-1 concentrations, are different according to the degree of glucose tolerance. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12181379/Effect_of_glucose_tolerance_status_on_PAI_1_plasma_levels_in_overweight_and_obese_subjects_ L2 - https://doi.org/10.1038/oby.2002.98 DB - PRIME DP - Unbound Medicine ER -