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Taurine modulates antioxidant potential and controls lipid peroxidation in the aorta of high fructose-fed rats.
J Biochem Mol Biol Biophys 2002; 6(2):129-33JB

Abstract

High dosage of fructose induces insulin resistance, glucose intolerance and alterations in plasma lipid profile in normal rats. Recently, it has been shown that these rats also develop oxidative stress, which plays a prominent role in diabetic pathology. We now report the effect of taurine on the susceptibility of the aorta to lipid peroxidation and also on the activities of enzymic and non-enzymic antioxidants in rats fed a high fructose-diet for 4 weeks. Fructose-fed rats were more susceptible to lipid peroxidation as measured by thiobarbituric acid reactivity, and antioxidant status was significantly lower. Taurine supplementation caused a significant reduction in the production of thiobarbituric acid--reactive substances and significant rises in antioxidant enzyme activities. The levels of lipid peroxides, diene conjugates, lipofuscin and hydroperoxides were significantly higher in fructose-fed rats. When these rats received taurine in drinking water, no peroxidative changes were observed. Increased aorta lipid peroxidation could play a role in the pathology associated with fructose-feeding, and taurine reduces the lipid peroxidation by inducing antioxidant enzymes.

Authors+Show Affiliations

Faculty of Science, Department of Biochemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12186769

Citation

Anitha Nandhini, A T., et al. "Taurine Modulates Antioxidant Potential and Controls Lipid Peroxidation in the Aorta of High Fructose-fed Rats." Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB : the Official Journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), vol. 6, no. 2, 2002, pp. 129-33.
Anitha Nandhini AT, Balakrishnan SD, Anuradha CV. Taurine modulates antioxidant potential and controls lipid peroxidation in the aorta of high fructose-fed rats. J Biochem Mol Biol Biophys. 2002;6(2):129-33.
Anitha Nandhini, A. T., Balakrishnan, S. D., & Anuradha, C. V. (2002). Taurine modulates antioxidant potential and controls lipid peroxidation in the aorta of high fructose-fed rats. Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB : the Official Journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), 6(2), pp. 129-33.
Anitha Nandhini AT, Balakrishnan SD, Anuradha CV. Taurine Modulates Antioxidant Potential and Controls Lipid Peroxidation in the Aorta of High Fructose-fed Rats. J Biochem Mol Biol Biophys. 2002;6(2):129-33. PubMed PMID: 12186769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taurine modulates antioxidant potential and controls lipid peroxidation in the aorta of high fructose-fed rats. AU - Anitha Nandhini,A T, AU - Balakrishnan,S D, AU - Anuradha,C V, PY - 2002/8/21/pubmed PY - 2002/10/22/medline PY - 2002/8/21/entrez SP - 129 EP - 33 JF - Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) JO - J. Biochem. Mol. Biol. Biophys. VL - 6 IS - 2 N2 - High dosage of fructose induces insulin resistance, glucose intolerance and alterations in plasma lipid profile in normal rats. Recently, it has been shown that these rats also develop oxidative stress, which plays a prominent role in diabetic pathology. We now report the effect of taurine on the susceptibility of the aorta to lipid peroxidation and also on the activities of enzymic and non-enzymic antioxidants in rats fed a high fructose-diet for 4 weeks. Fructose-fed rats were more susceptible to lipid peroxidation as measured by thiobarbituric acid reactivity, and antioxidant status was significantly lower. Taurine supplementation caused a significant reduction in the production of thiobarbituric acid--reactive substances and significant rises in antioxidant enzyme activities. The levels of lipid peroxides, diene conjugates, lipofuscin and hydroperoxides were significantly higher in fructose-fed rats. When these rats received taurine in drinking water, no peroxidative changes were observed. Increased aorta lipid peroxidation could play a role in the pathology associated with fructose-feeding, and taurine reduces the lipid peroxidation by inducing antioxidant enzymes. SN - 1025-8140 UR - https://www.unboundmedicine.com/medline/citation/12186769/Taurine_modulates_antioxidant_potential_and_controls_lipid_peroxidation_in_the_aorta_of_high_fructose_fed_rats_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -