Tags

Type your tag names separated by a space and hit enter

Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children.
Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63.AJ

Abstract

The rise in childhood asthma prevalence suggests a role for environmental factors in the etiology of this evolving epidemic; however, genetics also influence the occurrence of asthma. Glutathione S-transferase (GST) M1 may play a role in asthma and wheezing occurrence among those exposed to tobacco smoke, as it functions in pathways involved in asthma pathogenesis such as xenobiotic metabolism and antioxidant defenses. Effects of GSTM1 genotype, maternal smoking during pregnancy, and childhood environmental tobacco smoke (ETS) exposure on asthma and wheezing were investigated in 2,950 children enrolled in 4th, 7th, and 10th grade classrooms in 12 Southern California communities. The effects of in utero exposure to maternal smoking on asthma and wheezing occurrence were largely restricted to children with GSTM1 null genotype. Among GSTM1 null children, in utero exposure was associated with increased prevalence of early onset asthma (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.0-2.5), asthma with current symptoms (OR 1.7, 95% CI 1.1-2.8), persistent asthma (OR 1.6, 95% CI 1.1-2.4), lifetime history of wheezing (OR 1.8, 95% CI 1.3-2.5), wheezing with exercise (OR 2.1, 95% CI 1.3-3.3), wheezing requiring medication (OR 2.2, 95% CI 1.4-3.4), and emergency room visits in the past year (OR 3.7, 95% CI 1.9-7.3). Among children with GSTM1 (+) genotype, in utero exposure was not associated with asthma or wheezing. Our findings indicate that there are important long-term effects of in utero exposure in a genetically susceptible group of children.

Authors+Show Affiliations

Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA. gillilan@hsc.usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12186820

Citation

Gilliland, Frank D., et al. "Effects of Glutathione S-transferase M1, Maternal Smoking During Pregnancy, and Environmental Tobacco Smoke On Asthma and Wheezing in Children." American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 4, 2002, pp. 457-63.
Gilliland FD, Li YF, Dubeau L, et al. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2002;166(4):457-63.
Gilliland, F. D., Li, Y. F., Dubeau, L., Berhane, K., Avol, E., McConnell, R., Gauderman, W. J., & Peters, J. M. (2002). Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine, 166(4), 457-63.
Gilliland FD, et al. Effects of Glutathione S-transferase M1, Maternal Smoking During Pregnancy, and Environmental Tobacco Smoke On Asthma and Wheezing in Children. Am J Respir Crit Care Med. 2002 Aug 15;166(4):457-63. PubMed PMID: 12186820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. AU - Gilliland,Frank D, AU - Li,Yu-Fen, AU - Dubeau,Louis, AU - Berhane,Kiros, AU - Avol,Edward, AU - McConnell,Rob, AU - Gauderman,W James, AU - Peters,John M, PY - 2002/8/21/pubmed PY - 2002/9/7/medline PY - 2002/8/21/entrez SP - 457 EP - 63 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 166 IS - 4 N2 - The rise in childhood asthma prevalence suggests a role for environmental factors in the etiology of this evolving epidemic; however, genetics also influence the occurrence of asthma. Glutathione S-transferase (GST) M1 may play a role in asthma and wheezing occurrence among those exposed to tobacco smoke, as it functions in pathways involved in asthma pathogenesis such as xenobiotic metabolism and antioxidant defenses. Effects of GSTM1 genotype, maternal smoking during pregnancy, and childhood environmental tobacco smoke (ETS) exposure on asthma and wheezing were investigated in 2,950 children enrolled in 4th, 7th, and 10th grade classrooms in 12 Southern California communities. The effects of in utero exposure to maternal smoking on asthma and wheezing occurrence were largely restricted to children with GSTM1 null genotype. Among GSTM1 null children, in utero exposure was associated with increased prevalence of early onset asthma (odds ratio [OR] 1.6, 95% confidence interval [CI] 1.0-2.5), asthma with current symptoms (OR 1.7, 95% CI 1.1-2.8), persistent asthma (OR 1.6, 95% CI 1.1-2.4), lifetime history of wheezing (OR 1.8, 95% CI 1.3-2.5), wheezing with exercise (OR 2.1, 95% CI 1.3-3.3), wheezing requiring medication (OR 2.2, 95% CI 1.4-3.4), and emergency room visits in the past year (OR 3.7, 95% CI 1.9-7.3). Among children with GSTM1 (+) genotype, in utero exposure was not associated with asthma or wheezing. Our findings indicate that there are important long-term effects of in utero exposure in a genetically susceptible group of children. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/12186820/Effects_of_glutathione_S_transferase_M1_maternal_smoking_during_pregnancy_and_environmental_tobacco_smoke_on_asthma_and_wheezing_in_children_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.2112064?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -