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Leptin and metabolic syndrome in obese and non-obese children.
Horm Metab Res. 2002 Jul; 34(7):394-9.HM

Abstract

Metabolic syndrome is characterized by a clustering of metabolic abnormalities: insulin resistance - hyperinsulinemia, dyslipidemia (high triglycerides and low HDL - cholesterol serum concentrations), impaired glucose tolerance and/or type 2 diabetes, and hypertension. The aim of this study was to analyse the role of different variables of metabolic syndrome, including leptin, in 74 non-obese children and 68 children with non-syndromal obesity. As metabolic syndrome variables, we have included body mass index, waist circumference, trunk-to-total skinfolds (%), systolic blood pressure, diastolic blood pressure, glucose, uric acid, fasting insulin, triglycerides and high-density lipoprotein-cholesterol (HDL-C). Factor analysis showed 4 factors in each group. In non-obese children, waist circumference, BMI, fasting insulin, triglycerides, trunk-to-total skinfolds (%), leptin and uric acid loaded positively on factor 1, and HDL-C loaded negatively on this factor; systolic and diastolic blood pressure had high positive loadings in factor 2; HDL-C and leptin showed positive loadings and triglycerides and uric acid, negative loadings in factor 3; and, finally, glucose and insulin showed positive loadings in factor 4. These four factors explained 72.16 % of the total variance in the non-obese group. In obese children, BMI, waist circumference, leptin, diastolic blood pressure and systolic blood pressure loaded positively on factor 1; diastolic blood pressure, trunk-to-total skinfolds (%), uric acid and systolic blood pressure showed high positive loadings in factor 2; fasting insulin, glucose and triglycerides showed positive loadings in factor 3; and, finally, triglycerides showed positive loadings and HDL-C negative loadings in factor 4. These four factors explained 74.18 % of the total variance in the obese group. Our results point to a different homeostatic control of metabolic syndrome characteristics in obese and non-obese children. Leptin seems to play a key underlying role in metabolic syndrome, especially in the obese group.

Authors+Show Affiliations

E.U. Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Spain. lmoreno@posta.unizar.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12189588

Citation

Moreno, L A., et al. "Leptin and Metabolic Syndrome in Obese and Non-obese Children." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 34, no. 7, 2002, pp. 394-9.
Moreno LA, Pineda I, Rodríguez G, et al. Leptin and metabolic syndrome in obese and non-obese children. Horm Metab Res. 2002;34(7):394-9.
Moreno, L. A., Pineda, I., Rodríguez, G., Fleta, J., Giner, A., Juste, M. G., Sarría, A., & Bueno, M. (2002). Leptin and metabolic syndrome in obese and non-obese children. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 34(7), 394-9.
Moreno LA, et al. Leptin and Metabolic Syndrome in Obese and Non-obese Children. Horm Metab Res. 2002;34(7):394-9. PubMed PMID: 12189588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin and metabolic syndrome in obese and non-obese children. AU - Moreno,L A, AU - Pineda,I, AU - Rodríguez,G, AU - Fleta,J, AU - Giner,A, AU - Juste,M G, AU - Sarría,A, AU - Bueno,M, PY - 2002/8/22/pubmed PY - 2003/3/12/medline PY - 2002/8/22/entrez SP - 394 EP - 9 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 34 IS - 7 N2 - Metabolic syndrome is characterized by a clustering of metabolic abnormalities: insulin resistance - hyperinsulinemia, dyslipidemia (high triglycerides and low HDL - cholesterol serum concentrations), impaired glucose tolerance and/or type 2 diabetes, and hypertension. The aim of this study was to analyse the role of different variables of metabolic syndrome, including leptin, in 74 non-obese children and 68 children with non-syndromal obesity. As metabolic syndrome variables, we have included body mass index, waist circumference, trunk-to-total skinfolds (%), systolic blood pressure, diastolic blood pressure, glucose, uric acid, fasting insulin, triglycerides and high-density lipoprotein-cholesterol (HDL-C). Factor analysis showed 4 factors in each group. In non-obese children, waist circumference, BMI, fasting insulin, triglycerides, trunk-to-total skinfolds (%), leptin and uric acid loaded positively on factor 1, and HDL-C loaded negatively on this factor; systolic and diastolic blood pressure had high positive loadings in factor 2; HDL-C and leptin showed positive loadings and triglycerides and uric acid, negative loadings in factor 3; and, finally, glucose and insulin showed positive loadings in factor 4. These four factors explained 72.16 % of the total variance in the non-obese group. In obese children, BMI, waist circumference, leptin, diastolic blood pressure and systolic blood pressure loaded positively on factor 1; diastolic blood pressure, trunk-to-total skinfolds (%), uric acid and systolic blood pressure showed high positive loadings in factor 2; fasting insulin, glucose and triglycerides showed positive loadings in factor 3; and, finally, triglycerides showed positive loadings and HDL-C negative loadings in factor 4. These four factors explained 74.18 % of the total variance in the obese group. Our results point to a different homeostatic control of metabolic syndrome characteristics in obese and non-obese children. Leptin seems to play a key underlying role in metabolic syndrome, especially in the obese group. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/12189588/Leptin_and_metabolic_syndrome_in_obese_and_non_obese_children_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-33472 DB - PRIME DP - Unbound Medicine ER -