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Maggot versus conservative debridement therapy for the treatment of pressure ulcers.
Wound Repair Regen 2002 Jul-Aug; 10(4):208-14WR

Abstract

To define the efficacy and safety of maggot therapy, a cohort of 103 inpatients with 145 pressure ulcers was evaluated. Sixty-one ulcers in 50 patients received maggot therapy at some point during their monitored course; 84 ulcers in 70 patients did not. Debridement and wound healing could be quantified for 43 maggot-treated wounds and 49 conventionally treated wounds. Eighty percent of maggot-treated wounds were completely debrided, while only 48% of wounds were completely debrided with conventional therapy alone (p=0.021). Within 3 weeks, maggot-treated wounds contained one-third the necrotic tissue (p = 0.05) and twice the granulation tissue (p < 0.001), compared to non-maggot-treated wounds. Of the 31 measurable maggot-treated wounds monitored initially during conventional therapy, necrotic tissue decreased 0.2 cm(2) per week during conventional therapy, while total wound area increased 1.2 cm(2) per week. During maggot therapy, necrotic tissue decreased 0.8 cm(2) per week (p = 0.003) and total wound surface area decreased 1.2 cm2 per week (p = 0.001). Maggot therapy was more effective and efficient in debriding chronic pressure ulcers than were the conventional treatments prescribed. Patients readily accepted maggot therapy, and adverse events were uncommon.

Authors+Show Affiliations

Department of Pathology, University of California, Irvine, California 92697-4800, USA. rsherman@uci.edu

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12191002

Citation

Sherman, Ronald A.. "Maggot Versus Conservative Debridement Therapy for the Treatment of Pressure Ulcers." Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, vol. 10, no. 4, 2002, pp. 208-14.
Sherman RA. Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair Regen. 2002;10(4):208-14.
Sherman, R. A. (2002). Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, 10(4), pp. 208-14.
Sherman RA. Maggot Versus Conservative Debridement Therapy for the Treatment of Pressure Ulcers. Wound Repair Regen. 2002;10(4):208-14. PubMed PMID: 12191002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maggot versus conservative debridement therapy for the treatment of pressure ulcers. A1 - Sherman,Ronald A, PY - 2002/8/23/pubmed PY - 2002/11/26/medline PY - 2002/8/23/entrez SP - 208 EP - 14 JF - Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society JO - Wound Repair Regen VL - 10 IS - 4 N2 - To define the efficacy and safety of maggot therapy, a cohort of 103 inpatients with 145 pressure ulcers was evaluated. Sixty-one ulcers in 50 patients received maggot therapy at some point during their monitored course; 84 ulcers in 70 patients did not. Debridement and wound healing could be quantified for 43 maggot-treated wounds and 49 conventionally treated wounds. Eighty percent of maggot-treated wounds were completely debrided, while only 48% of wounds were completely debrided with conventional therapy alone (p=0.021). Within 3 weeks, maggot-treated wounds contained one-third the necrotic tissue (p = 0.05) and twice the granulation tissue (p < 0.001), compared to non-maggot-treated wounds. Of the 31 measurable maggot-treated wounds monitored initially during conventional therapy, necrotic tissue decreased 0.2 cm(2) per week during conventional therapy, while total wound area increased 1.2 cm(2) per week. During maggot therapy, necrotic tissue decreased 0.8 cm(2) per week (p = 0.003) and total wound surface area decreased 1.2 cm2 per week (p = 0.001). Maggot therapy was more effective and efficient in debriding chronic pressure ulcers than were the conventional treatments prescribed. Patients readily accepted maggot therapy, and adverse events were uncommon. SN - 1067-1927 UR - https://www.unboundmedicine.com/medline/citation/12191002/Maggot_versus_conservative_debridement_therapy_for_the_treatment_of_pressure_ulcers_ L2 - https://doi.org/10.1046/j.1524-475x.2002.10403.x DB - PRIME DP - Unbound Medicine ER -