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Maternal vitamin use and reduced risk of neuroblastoma.
Epidemiology. 2002 Sep; 13(5):575-80.E

Abstract

BACKGROUND

Previous studies have suggested that maternal vitamin use during pregnancy may reduce the incidence of childhood brain tumors. Using data from a large North American study, we conducted an analysis to investigate maternal vitamin use and neuroblastoma in offspring.

METHODS

Cases were children diagnosed with neuroblastoma over the period 1 May 1992 to 30 April 1994 at Children's Cancer Group and Pediatric Oncology Group institutions throughout the United States and Canada. One matched control was selected for each case using random-digit dialing. We obtained vitamin use information during specific periods before and during pregnancy from 538 case and 504 control mothers through telephone interviews.

RESULTS

Daily vitamin and mineral use in the month before pregnancy and in each trimester was associated with a 30-40% reduction in risk of neuroblastoma. For example, daily use in the second trimester had an odds ratio of 0.6 (95% confidence interval = 0.4-0.9). We were unable to isolate the effects of specific vitamins or minerals. Neither age at diagnosis nor oncogene amplification status materially altered the results.

CONCLUSIONS

The results of this study suggest that vitamin use during pregnancy might reduce incidence of neuroblastoma, consistent with findings for other childhood cancers.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health University of North Carolina, Chapel Hill, NC, USA. andy_olshan@unc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12192228

Citation

Olshan, Andrew F., et al. "Maternal Vitamin Use and Reduced Risk of Neuroblastoma." Epidemiology (Cambridge, Mass.), vol. 13, no. 5, 2002, pp. 575-80.
Olshan AF, Smith JC, Bondy ML, et al. Maternal vitamin use and reduced risk of neuroblastoma. Epidemiology. 2002;13(5):575-80.
Olshan, A. F., Smith, J. C., Bondy, M. L., Neglia, J. P., & Pollock, B. H. (2002). Maternal vitamin use and reduced risk of neuroblastoma. Epidemiology (Cambridge, Mass.), 13(5), 575-80.
Olshan AF, et al. Maternal Vitamin Use and Reduced Risk of Neuroblastoma. Epidemiology. 2002;13(5):575-80. PubMed PMID: 12192228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal vitamin use and reduced risk of neuroblastoma. AU - Olshan,Andrew F, AU - Smith,Joanna C, AU - Bondy,Melissa L, AU - Neglia,Joseph P, AU - Pollock,Brad H, PY - 2002/8/23/pubmed PY - 2002/10/3/medline PY - 2002/8/23/entrez SP - 575 EP - 80 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 13 IS - 5 N2 - BACKGROUND: Previous studies have suggested that maternal vitamin use during pregnancy may reduce the incidence of childhood brain tumors. Using data from a large North American study, we conducted an analysis to investigate maternal vitamin use and neuroblastoma in offspring. METHODS: Cases were children diagnosed with neuroblastoma over the period 1 May 1992 to 30 April 1994 at Children's Cancer Group and Pediatric Oncology Group institutions throughout the United States and Canada. One matched control was selected for each case using random-digit dialing. We obtained vitamin use information during specific periods before and during pregnancy from 538 case and 504 control mothers through telephone interviews. RESULTS: Daily vitamin and mineral use in the month before pregnancy and in each trimester was associated with a 30-40% reduction in risk of neuroblastoma. For example, daily use in the second trimester had an odds ratio of 0.6 (95% confidence interval = 0.4-0.9). We were unable to isolate the effects of specific vitamins or minerals. Neither age at diagnosis nor oncogene amplification status materially altered the results. CONCLUSIONS: The results of this study suggest that vitamin use during pregnancy might reduce incidence of neuroblastoma, consistent with findings for other childhood cancers. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/12192228/Maternal_vitamin_use_and_reduced_risk_of_neuroblastoma_ L2 - https://doi.org/10.1097/00001648-200209000-00014 DB - PRIME DP - Unbound Medicine ER -