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Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients.
Graefes Arch Clin Exp Ophthalmol. 2002 Aug; 240(8):658-65.GA

Abstract

BACKGROUND

The aim of this study was to evaluate the diagnostic usefulness of the FDT perimeter protocol (C-20-5) in combination with a database system for analysis of single test locations.

METHODS

One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy, elevated intraocular pressure, no visual field defects in standard white-on-white perimetry), 199 "perimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy and visual field defects), and 151 control eyes underwent FDT screening and conventional white-on-white perimetry. Four repeated measurements were carried out in 15 glaucoma patients at 2-h intervals to judge reproducibility of all test locations. The present screening strategy begins testing at the normal 5% probability level. If a stimulus is not detected, further targets are presented. FDT-Viewfinder and statistics software were used for case-wise recalculation of all missed localized probability levels and correlation with corresponding test locations using conventional perimetry.

RESULTS

Analysis of repeated measurements in patients reveals that variation of single test points can be considerable. However, the numbers of missed test-stimuli calculated globally or in quadrants are significantly correlated with corresponding Octopus visual field defects (Spearman rank correlation P<0.001). Using a predefined specificity of 96% in control eyes, 11% of ocular hypertensive eyes, 28.5% of "preperimetric" glaucoma eyes and 86.9% of "perimetric" glaucoma eyes have been classified glaucomatous using an overall score and with consideration of different cut-off points in right and left eyes.

CONCLUSION

Point-wise analysis of FDT screening results can be helpful for classification of patient groups and consideration of the individual learning curve in repeated measurements. The C-20-5 protocol of the FDT perimeter is able to detect a considerable proportion of glaucomatous patients.

Authors+Show Affiliations

Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg at Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. folkert.horn@augen.imed.uni-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12192460

Citation

Horn, Folkert K., et al. "Testing for Glaucoma With Frequency-doubling Perimetry in Normals, Ocular Hypertensives, and Glaucoma Patients." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 240, no. 8, 2002, pp. 658-65.
Horn FK, Wakili N, Jünemann AM, et al. Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients. Graefes Arch Clin Exp Ophthalmol. 2002;240(8):658-65.
Horn, F. K., Wakili, N., Jünemann, A. M., & Korth, M. (2002). Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 240(8), 658-65.
Horn FK, et al. Testing for Glaucoma With Frequency-doubling Perimetry in Normals, Ocular Hypertensives, and Glaucoma Patients. Graefes Arch Clin Exp Ophthalmol. 2002;240(8):658-65. PubMed PMID: 12192460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients. AU - Horn,Folkert K, AU - Wakili,Nina, AU - Jünemann,Anselm M, AU - Korth,Matthias, Y1 - 2002/07/05/ PY - 2002/01/17/received PY - 2002/04/30/revised PY - 2002/05/22/accepted PY - 2002/8/23/pubmed PY - 2002/12/27/medline PY - 2002/8/23/entrez SP - 658 EP - 65 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 240 IS - 8 N2 - BACKGROUND: The aim of this study was to evaluate the diagnostic usefulness of the FDT perimeter protocol (C-20-5) in combination with a database system for analysis of single test locations. METHODS: One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy, elevated intraocular pressure, no visual field defects in standard white-on-white perimetry), 199 "perimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy and visual field defects), and 151 control eyes underwent FDT screening and conventional white-on-white perimetry. Four repeated measurements were carried out in 15 glaucoma patients at 2-h intervals to judge reproducibility of all test locations. The present screening strategy begins testing at the normal 5% probability level. If a stimulus is not detected, further targets are presented. FDT-Viewfinder and statistics software were used for case-wise recalculation of all missed localized probability levels and correlation with corresponding test locations using conventional perimetry. RESULTS: Analysis of repeated measurements in patients reveals that variation of single test points can be considerable. However, the numbers of missed test-stimuli calculated globally or in quadrants are significantly correlated with corresponding Octopus visual field defects (Spearman rank correlation P<0.001). Using a predefined specificity of 96% in control eyes, 11% of ocular hypertensive eyes, 28.5% of "preperimetric" glaucoma eyes and 86.9% of "perimetric" glaucoma eyes have been classified glaucomatous using an overall score and with consideration of different cut-off points in right and left eyes. CONCLUSION: Point-wise analysis of FDT screening results can be helpful for classification of patient groups and consideration of the individual learning curve in repeated measurements. The C-20-5 protocol of the FDT perimeter is able to detect a considerable proportion of glaucomatous patients. SN - 0721-832X UR - https://www.unboundmedicine.com/medline/citation/12192460/Testing_for_glaucoma_with_frequency_doubling_perimetry_in_normals_ocular_hypertensives_and_glaucoma_patients_ L2 - https://dx.doi.org/10.1007/s00417-002-0512-9 DB - PRIME DP - Unbound Medicine ER -