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The genomics of yeast responses to environmental stress and starvation.
Funct Integr Genomics. 2002 Sep; 2(4-5):181-92.FI

Abstract

Unicellular organisms such as yeast have evolved to survive constant fluctuations in their external surroundings by rapidly adapting their internal systems to meet the challenges of each new environment. One aspect of this cellular adaptation is the reorganization of genomic expression to the program required for growth in each environment. The reprogramming of genomic expression can be unveiled using DNA microarrays, which measure the relative transcript abundance of essentially every gene in an organism's genome. Characterizing environmentally triggered gene expression changes provides insights into when, where, and how each gene is expressed and offers a glimpse at the physiological response of the cells to changes in their surroundings. This review will focus on the genomic expression responses of the budding yeast Saccharomyces cerevisiae to diverse environmental changes, highlighting some of the themes that have emerged from the collection of published yeast genomic expression studies. The results of these studies present insights as to how yeast cells sense and respond to each new environment, and suggest mechanisms that this organism uses to survive stressful environmental changes.

Authors+Show Affiliations

Department of Genome Science, Lawrence Berkeley National Laboratory, 1 Cyclotron Road 84-355, Berkeley, CA 94720, USA. apgasch@lbl.govNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12192591

Citation

Gasch, Audrey P., and Margaret Werner-Washburne. "The Genomics of Yeast Responses to Environmental Stress and Starvation." Functional & Integrative Genomics, vol. 2, no. 4-5, 2002, pp. 181-92.
Gasch AP, Werner-Washburne M. The genomics of yeast responses to environmental stress and starvation. Funct Integr Genomics. 2002;2(4-5):181-92.
Gasch, A. P., & Werner-Washburne, M. (2002). The genomics of yeast responses to environmental stress and starvation. Functional & Integrative Genomics, 2(4-5), 181-92.
Gasch AP, Werner-Washburne M. The Genomics of Yeast Responses to Environmental Stress and Starvation. Funct Integr Genomics. 2002;2(4-5):181-92. PubMed PMID: 12192591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genomics of yeast responses to environmental stress and starvation. AU - Gasch,Audrey P, AU - Werner-Washburne,Margaret, Y1 - 2002/04/30/ PY - 2002/01/18/received PY - 2002/03/21/accepted PY - 2002/8/23/pubmed PY - 2003/2/8/medline PY - 2002/8/23/entrez SP - 181 EP - 92 JF - Functional & integrative genomics JO - Funct Integr Genomics VL - 2 IS - 4-5 N2 - Unicellular organisms such as yeast have evolved to survive constant fluctuations in their external surroundings by rapidly adapting their internal systems to meet the challenges of each new environment. One aspect of this cellular adaptation is the reorganization of genomic expression to the program required for growth in each environment. The reprogramming of genomic expression can be unveiled using DNA microarrays, which measure the relative transcript abundance of essentially every gene in an organism's genome. Characterizing environmentally triggered gene expression changes provides insights into when, where, and how each gene is expressed and offers a glimpse at the physiological response of the cells to changes in their surroundings. This review will focus on the genomic expression responses of the budding yeast Saccharomyces cerevisiae to diverse environmental changes, highlighting some of the themes that have emerged from the collection of published yeast genomic expression studies. The results of these studies present insights as to how yeast cells sense and respond to each new environment, and suggest mechanisms that this organism uses to survive stressful environmental changes. SN - 1438-793X UR - https://www.unboundmedicine.com/medline/citation/12192591/The_genomics_of_yeast_responses_to_environmental_stress_and_starvation_ DB - PRIME DP - Unbound Medicine ER -
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