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A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3.
Mol Psychiatry. 2002; 7(7):734-44.MP

Abstract

The present study reports a genomewide scan using linkage analysis for risk genes involved in bipolar disorder with 613 microsatellite markers including additional testing of promising regions. As previously published significant linkage was obtained at chromosome 12q24.3 with a two-point parametric lod score of 3.42 at D12S1639 including all members in both families (empirical P-value 0.00004, genome-wide P-value 0.0417). The multipoint parametric lod score at D12S1639 was 3.63 (genome-wide P-value 0.0265). At chromosome 1p22-p21 a parametric, affecteds-only two-point lod score of 2.75 at marker D1S216 was found (empirical P-value 0.0002, genome-wide P-value 0.1622). A three-point lod score of 2.98 (genome-wide P-value 0.1022) at D1S216, and a multipoint non-parametric analysis with a maximum NPL-all score of 17.60 (P-value 0.00079) at D1S216 further supported this finding. A number of additional loci on chromosomes 4p16, 6q14-q22, 10q26 and 16p13.3 yielded parametric lod scores around or above 2.

Authors+Show Affiliations

Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Skovagervej, Risskov, Denmark. he@psykiatri.aaa.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12192618

Citation

Ewald, H, et al. "A Genome-wide Scan Shows Significant Linkage Between Bipolar Disorder and Chromosome 12q24.3 and Suggestive Linkage to Chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3." Molecular Psychiatry, vol. 7, no. 7, 2002, pp. 734-44.
Ewald H, Flint T, Kruse TA, et al. A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry. 2002;7(7):734-44.
Ewald, H., Flint, T., Kruse, T. A., & Mors, O. (2002). A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Molecular Psychiatry, 7(7), 734-44.
Ewald H, et al. A Genome-wide Scan Shows Significant Linkage Between Bipolar Disorder and Chromosome 12q24.3 and Suggestive Linkage to Chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry. 2002;7(7):734-44. PubMed PMID: 12192618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. AU - Ewald,H, AU - Flint,T, AU - Kruse,T A, AU - Mors,O, PY - 2001/09/04/received PY - 2001/10/04/revised PY - 2001/11/21/accepted PY - 2002/8/23/pubmed PY - 2003/2/26/medline PY - 2002/8/23/entrez SP - 734 EP - 44 JF - Molecular psychiatry JO - Mol. Psychiatry VL - 7 IS - 7 N2 - The present study reports a genomewide scan using linkage analysis for risk genes involved in bipolar disorder with 613 microsatellite markers including additional testing of promising regions. As previously published significant linkage was obtained at chromosome 12q24.3 with a two-point parametric lod score of 3.42 at D12S1639 including all members in both families (empirical P-value 0.00004, genome-wide P-value 0.0417). The multipoint parametric lod score at D12S1639 was 3.63 (genome-wide P-value 0.0265). At chromosome 1p22-p21 a parametric, affecteds-only two-point lod score of 2.75 at marker D1S216 was found (empirical P-value 0.0002, genome-wide P-value 0.1622). A three-point lod score of 2.98 (genome-wide P-value 0.1022) at D1S216, and a multipoint non-parametric analysis with a maximum NPL-all score of 17.60 (P-value 0.00079) at D1S216 further supported this finding. A number of additional loci on chromosomes 4p16, 6q14-q22, 10q26 and 16p13.3 yielded parametric lod scores around or above 2. SN - 1359-4184 UR - https://www.unboundmedicine.com/medline/citation/12192618/A_genome_wide_scan_shows_significant_linkage_between_bipolar_disorder_and_chromosome_12q24_3_and_suggestive_linkage_to_chromosomes_1p22_21_4p16_6q14_22_10q26_and_16p13_3_ L2 - http://dx.doi.org/10.1038/sj.mp.4001074 DB - PRIME DP - Unbound Medicine ER -