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New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume.
J Nat Prod 2002; 65(8):1151-5JN

Abstract

The methanolic extract from the fresh flowers of Prunus mume exhibited inhibitory effects against aldose reductase and platelet aggregation. From the methanolic extract, two new flavonol oligoglycosides, 2' '-O-acetylrutin and 2' '-O-acetyl-3'-O-methylrutin, and two new polyacylated sucroses, prunoses I and II, were isolated together with 11 known constituents. The structures of 2' '-O-acetylrutin, 2' '-O-acetyl-3'-O-methylrutin, and prunoses I and II were determined on the basis of chemical and physicochemical evidence as quercetin 3-O-alpha-L-rhamnopyranosyl(1-->6)-2' '-O-acetyl-beta-D-glucopyranoside, 3'-O-methylquercetin 3-O-alpha-L-rhamnopyranosyl(1-->6)-2' '-O-acetyl-beta-D-glucopyranoside, 1,4,3',4',6'-penta-O-acetyl-6-O-p-coumaroylsucrose, and 1,3',4',6'-tetra-O-acetyl-6-O-p-coumaroylsucrose, respectively. The flavonol glycosides and prunose I were found to inhibit aldose reductase, while prunoses I and II inhibited platelet aggregation induced by thrombin.

Authors+Show Affiliations

Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Japan. shoyaku@mb.kyoto-phu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12193020

Citation

Yoshikawa, Masayuki, et al. "New Flavonol Oligoglycosides and Polyacylated Sucroses With Inhibitory Effects On Aldose Reductase and Platelet Aggregation From the Flowers of Prunus Mume." Journal of Natural Products, vol. 65, no. 8, 2002, pp. 1151-5.
Yoshikawa M, Murakami T, Ishiwada T, et al. New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume. J Nat Prod. 2002;65(8):1151-5.
Yoshikawa, M., Murakami, T., Ishiwada, T., Morikawa, T., Kagawa, M., Higashi, Y., & Matsuda, H. (2002). New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume. Journal of Natural Products, 65(8), pp. 1151-5.
Yoshikawa M, et al. New Flavonol Oligoglycosides and Polyacylated Sucroses With Inhibitory Effects On Aldose Reductase and Platelet Aggregation From the Flowers of Prunus Mume. J Nat Prod. 2002;65(8):1151-5. PubMed PMID: 12193020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume. AU - Yoshikawa,Masayuki, AU - Murakami,Toshiyuki, AU - Ishiwada,Tomoko, AU - Morikawa,Toshio, AU - Kagawa,Masatomo, AU - Higashi,Yoshihiko, AU - Matsuda,Hisashi, PY - 2002/8/24/pubmed PY - 2002/10/22/medline PY - 2002/8/24/entrez SP - 1151 EP - 5 JF - Journal of natural products JO - J. Nat. Prod. VL - 65 IS - 8 N2 - The methanolic extract from the fresh flowers of Prunus mume exhibited inhibitory effects against aldose reductase and platelet aggregation. From the methanolic extract, two new flavonol oligoglycosides, 2' '-O-acetylrutin and 2' '-O-acetyl-3'-O-methylrutin, and two new polyacylated sucroses, prunoses I and II, were isolated together with 11 known constituents. The structures of 2' '-O-acetylrutin, 2' '-O-acetyl-3'-O-methylrutin, and prunoses I and II were determined on the basis of chemical and physicochemical evidence as quercetin 3-O-alpha-L-rhamnopyranosyl(1-->6)-2' '-O-acetyl-beta-D-glucopyranoside, 3'-O-methylquercetin 3-O-alpha-L-rhamnopyranosyl(1-->6)-2' '-O-acetyl-beta-D-glucopyranoside, 1,4,3',4',6'-penta-O-acetyl-6-O-p-coumaroylsucrose, and 1,3',4',6'-tetra-O-acetyl-6-O-p-coumaroylsucrose, respectively. The flavonol glycosides and prunose I were found to inhibit aldose reductase, while prunoses I and II inhibited platelet aggregation induced by thrombin. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/12193020/New_flavonol_oligoglycosides_and_polyacylated_sucroses_with_inhibitory_effects_on_aldose_reductase_and_platelet_aggregation_from_the_flowers_of_Prunus_mume_ L2 - https://dx.doi.org/10.1021/np020058m DB - PRIME DP - Unbound Medicine ER -