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Role of superoxide dismutases in oxidative damage and neurodegenerative disorders.
Neuroscientist. 2002 Aug; 8(4):323-34.N

Abstract

In recent years, oxidative stress has been implicated in a variety of degenerative processes, diseases, and syndromes. Some of these include atherosclerosis, myocardial infarction, stroke, and ischemia/reperfusion injury; chronic and acute inflammatory conditions such as wound healing; central nervous system disorders such as forms of familial amyotrophic lateral sclerosis (ALS) and glutathione peroxidase-linked adolescent seizures; Parkinson's disease and Alzheimer's dementia; and a variety of other age-related disorders. Among the various biochemical events associated with these conditions, emerging evidence suggests the formation of superoxide anion and expression/activity of its endogenous scavenger, superoxide dismutase (SOD), as a common denominator. This review summarizes the function of SOD under normal physiological conditions as well as its role in the cellular and molecular mechanisms underlying oxidative tissue damage and neurological abnormalities. Experimental evidence from laboratory animals that either overexpress (transgenics) or are deficient (knockouts) in antioxidant enzyme/protein levels and the genetic SOD mutations observed in some familial cases of ALS are also discussed.

Authors+Show Affiliations

Department of Neurosurgery, Department of Neurology and Neurological Sciences, Program in Neurosciences, Stanford University School of Medicine, Stanford, California, USA. chile@stanford.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12194501

Citation

Maier, Carolina M., and Pak H. Chan. "Role of Superoxide Dismutases in Oxidative Damage and Neurodegenerative Disorders." The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry, vol. 8, no. 4, 2002, pp. 323-34.
Maier CM, Chan PH. Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist. 2002;8(4):323-34.
Maier, C. M., & Chan, P. H. (2002). Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry, 8(4), 323-34.
Maier CM, Chan PH. Role of Superoxide Dismutases in Oxidative Damage and Neurodegenerative Disorders. Neuroscientist. 2002;8(4):323-34. PubMed PMID: 12194501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. AU - Maier,Carolina M, AU - Chan,Pak H, PY - 2002/8/27/pubmed PY - 2003/1/16/medline PY - 2002/8/27/entrez SP - 323 EP - 34 JF - The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry JO - Neuroscientist VL - 8 IS - 4 N2 - In recent years, oxidative stress has been implicated in a variety of degenerative processes, diseases, and syndromes. Some of these include atherosclerosis, myocardial infarction, stroke, and ischemia/reperfusion injury; chronic and acute inflammatory conditions such as wound healing; central nervous system disorders such as forms of familial amyotrophic lateral sclerosis (ALS) and glutathione peroxidase-linked adolescent seizures; Parkinson's disease and Alzheimer's dementia; and a variety of other age-related disorders. Among the various biochemical events associated with these conditions, emerging evidence suggests the formation of superoxide anion and expression/activity of its endogenous scavenger, superoxide dismutase (SOD), as a common denominator. This review summarizes the function of SOD under normal physiological conditions as well as its role in the cellular and molecular mechanisms underlying oxidative tissue damage and neurological abnormalities. Experimental evidence from laboratory animals that either overexpress (transgenics) or are deficient (knockouts) in antioxidant enzyme/protein levels and the genetic SOD mutations observed in some familial cases of ALS are also discussed. SN - 1073-8584 UR - https://www.unboundmedicine.com/medline/citation/12194501/Role_of_superoxide_dismutases_in_oxidative_damage_and_neurodegenerative_disorders_ L2 - https://journals.sagepub.com/doi/10.1177/107385840200800408?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -