TY - JOUR T1 - Clinical course and the role of shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997-2000, in Germany and Austria: a prospective study. AU - Gerber,Angela, AU - Karch,Helge, AU - Allerberger,Franz, AU - Verweyen,Hege M, AU - Zimmerhackl,Lothar B, Y1 - 2002/08/02/ PY - 2002/02/04/received PY - 2002/04/12/revised PY - 2002/8/27/pubmed PY - 2002/9/18/medline PY - 2002/8/27/entrez SP - 493 EP - 500 JF - The Journal of infectious diseases JO - J Infect Dis VL - 186 IS - 4 N2 - Hemolytic-uremic syndrome (HUS) is mainly associated with foodborne infections by Shiga toxin-producing Escherichia coli (STEC). From January 1997 through December 2000, 394 children with HUS were evaluated in a prospective multicenter surveillance study in Germany and Austria (incidences, 0.7/100,000 and 0.4/100,000 children <15 years old, respectively). Blood leukocytosis was associated with increased detection of STEC in stool cultures (P<.01) and a more severe disease course. Risk of death was associated with cerebral involvement (P<.01). Most strikingly, non-O157:H7 STEC were detected in 43% of stool cultures of patients with HUS: O26 was detected in 15%, sorbitol-fermenting O157:H(-) in 10%, O145 in 9%, O103 in 3%, and O111 in 43%. Patients with O157:H7 serotypes required dialysis for a longer time and had bloody diarrhea detected more frequently, compared with patients with non-O157:H7 serotypes (P<.05). This large study in children with HUS underlines the rising importance of non-O157:H7 serotypes, and, despite increased public awareness, the number of patients remained unchanged. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12195376/Clinical_course_and_the_role_of_shiga_toxin_producing_Escherichia_coli_infection_in_the_hemolytic_uremic_syndrome_in_pediatric_patients_1997_2000_in_Germany_and_Austria:_a_prospective_study_ DB - PRIME DP - Unbound Medicine ER -