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Terbinafine: efficacy and tolerability in young children with tinea capitis due to Microsporum canis.
J Eur Acad Dermatol Venereol. 2002 May; 16(3):228-30.JE

Abstract

AIMS

We carried out an open, prospective, uncontrolled study to evaluate the efficacy and tolerability of terbinafine in the treatment of young children with tinea capitis due to Microsporum canis.

METHODS

A total of 83 healthy, immunocompetent children (age range 2-13 years) were enrolled in eight centres in Estonia, Latvia and Lithuania. Patients received oral terbinafine in dosages based on weight, 62.5 mg for those weighing 10-20 kg, 125 mg for 20-40 kg, plus application of topical 1% terbinafine cream twice daily to affected areas. Treatment lasted for 4 weeks, followed by an 8-week observation (treatment-free) period. All the subjects were assessed for efficacy and tolerability at 12 weeks.

RESULTS

Eighty-one subjects were available for assessment at 12 weeks: 32 had completely recovered, with no evidence of relapse during the observation period, and 21 showed mycological cure, but presented residual physical signs of infection. Thus the effective cure rate was 65.4% in an infection known to be more difficult to cure than other causes of tinea capitis. Terbinafine was well tolerated by these children.

CONCLUSIONS

This study showed effective cure of two-thirds of 81 cases of tinea capitis caused by M. canis with a 4-week course of treatment. As one-third of the cases did not respond to treatment, we suggest using combined oral and topical treatment with terbinafine in children with tinea capitis caused by M. canis.

Authors+Show Affiliations

Department of Dermatology and Venereology, Tartu University, Lossi 21/23, 51003 Tartu, Estonia. helgi.silm@kliinikum.eeNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12195561

Citation

Silm, H, and M Karelson. "Terbinafine: Efficacy and Tolerability in Young Children With Tinea Capitis Due to Microsporum Canis." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 16, no. 3, 2002, pp. 228-30.
Silm H, Karelson M. Terbinafine: efficacy and tolerability in young children with tinea capitis due to Microsporum canis. J Eur Acad Dermatol Venereol. 2002;16(3):228-30.
Silm, H., & Karelson, M. (2002). Terbinafine: efficacy and tolerability in young children with tinea capitis due to Microsporum canis. Journal of the European Academy of Dermatology and Venereology : JEADV, 16(3), 228-30.
Silm H, Karelson M. Terbinafine: Efficacy and Tolerability in Young Children With Tinea Capitis Due to Microsporum Canis. J Eur Acad Dermatol Venereol. 2002;16(3):228-30. PubMed PMID: 12195561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Terbinafine: efficacy and tolerability in young children with tinea capitis due to Microsporum canis. AU - Silm,H, AU - Karelson,M, PY - 2002/8/28/pubmed PY - 2002/11/26/medline PY - 2002/8/28/entrez SP - 228 EP - 30 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 16 IS - 3 N2 - AIMS: We carried out an open, prospective, uncontrolled study to evaluate the efficacy and tolerability of terbinafine in the treatment of young children with tinea capitis due to Microsporum canis. METHODS: A total of 83 healthy, immunocompetent children (age range 2-13 years) were enrolled in eight centres in Estonia, Latvia and Lithuania. Patients received oral terbinafine in dosages based on weight, 62.5 mg for those weighing 10-20 kg, 125 mg for 20-40 kg, plus application of topical 1% terbinafine cream twice daily to affected areas. Treatment lasted for 4 weeks, followed by an 8-week observation (treatment-free) period. All the subjects were assessed for efficacy and tolerability at 12 weeks. RESULTS: Eighty-one subjects were available for assessment at 12 weeks: 32 had completely recovered, with no evidence of relapse during the observation period, and 21 showed mycological cure, but presented residual physical signs of infection. Thus the effective cure rate was 65.4% in an infection known to be more difficult to cure than other causes of tinea capitis. Terbinafine was well tolerated by these children. CONCLUSIONS: This study showed effective cure of two-thirds of 81 cases of tinea capitis caused by M. canis with a 4-week course of treatment. As one-third of the cases did not respond to treatment, we suggest using combined oral and topical treatment with terbinafine in children with tinea capitis caused by M. canis. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/12195561/Terbinafine:_efficacy_and_tolerability_in_young_children_with_tinea_capitis_due_to_Microsporum_canis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0926-9959&date=2002&volume=16&issue=3&spage=228 DB - PRIME DP - Unbound Medicine ER -