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Overexpression of fibrinogen in ApoE*3-Leiden transgenic mice does not influence the progression of diet-induced atherosclerosis.
Thromb Haemost. 2002 Aug; 88(2):329-34.TH

Abstract

Although many epidemiological studies have shown an association between hyperfibrinogenemia and atherosclerosis, it is not established whether elevated fibrinogen has an etiological role in the pathogenesis or is only a reflection of the ongoing disease. We have studied the contribution of fibrinogen to the development of atherosclerosis in atherosclerosis-prone ApoE*3-Leiden mice that have been cross-bred with transgenic mice overexpressing fibrinogen. Genetic compound offspring were used to evaluate the progression of atherosclerotic lesions after being fed an atherogenic diet for 7 weeks. It was observed that the lesion area of the plaques as well as the severity of the lesions in the aortic valve was comparable in control single transgenic ApoE*3-Leiden mice and in double transgenic apoE*3-Leiden mice overexpressing fibrinogen. No thrombus or fibrin deposition was observed in atherosclerotic lesions in either group of mice. These results indicate that elevated plasma fibrinogen concentrations in ApoE*3-Leiden transgenic mice do not affect the progression of diet-induced atherosclerotic lesions.

Authors+Show Affiliations

Department of Vascular and Connective Tissue Research, Gaubius Laboratory, TNO-PG, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12195708

Citation

Rezaee, F, et al. "Overexpression of Fibrinogen in ApoE*3-Leiden Transgenic Mice Does Not Influence the Progression of Diet-induced Atherosclerosis." Thrombosis and Haemostasis, vol. 88, no. 2, 2002, pp. 329-34.
Rezaee F, Gijbels MJ, Offerman EH, et al. Overexpression of fibrinogen in ApoE*3-Leiden transgenic mice does not influence the progression of diet-induced atherosclerosis. Thromb Haemost. 2002;88(2):329-34.
Rezaee, F., Gijbels, M. J., Offerman, E. H., van der Linden, M., De Maat, M. P., & Verheijen, J. H. (2002). Overexpression of fibrinogen in ApoE*3-Leiden transgenic mice does not influence the progression of diet-induced atherosclerosis. Thrombosis and Haemostasis, 88(2), 329-34.
Rezaee F, et al. Overexpression of Fibrinogen in ApoE*3-Leiden Transgenic Mice Does Not Influence the Progression of Diet-induced Atherosclerosis. Thromb Haemost. 2002;88(2):329-34. PubMed PMID: 12195708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overexpression of fibrinogen in ApoE*3-Leiden transgenic mice does not influence the progression of diet-induced atherosclerosis. AU - Rezaee,F, AU - Gijbels,M J, AU - Offerman,E H, AU - van der Linden,M, AU - De Maat,M P M, AU - Verheijen,J H, PY - 2002/8/28/pubmed PY - 2003/7/12/medline PY - 2002/8/28/entrez SP - 329 EP - 34 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 88 IS - 2 N2 - Although many epidemiological studies have shown an association between hyperfibrinogenemia and atherosclerosis, it is not established whether elevated fibrinogen has an etiological role in the pathogenesis or is only a reflection of the ongoing disease. We have studied the contribution of fibrinogen to the development of atherosclerosis in atherosclerosis-prone ApoE*3-Leiden mice that have been cross-bred with transgenic mice overexpressing fibrinogen. Genetic compound offspring were used to evaluate the progression of atherosclerotic lesions after being fed an atherogenic diet for 7 weeks. It was observed that the lesion area of the plaques as well as the severity of the lesions in the aortic valve was comparable in control single transgenic ApoE*3-Leiden mice and in double transgenic apoE*3-Leiden mice overexpressing fibrinogen. No thrombus or fibrin deposition was observed in atherosclerotic lesions in either group of mice. These results indicate that elevated plasma fibrinogen concentrations in ApoE*3-Leiden transgenic mice do not affect the progression of diet-induced atherosclerotic lesions. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/12195708/Overexpression_of_fibrinogen_in_ApoE_3_Leiden_transgenic_mice_does_not_influence_the_progression_of_diet_induced_atherosclerosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12195708.ui DB - PRIME DP - Unbound Medicine ER -