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Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals.

Abstract

BACKGROUND

Decreases in immune responsiveness with age contribute to the increased incidence and severity of infectious disease among elderly adults. The immune response to immunization also decreases with advancing age. Lifestyle factors (exercise, diet) have been established to play an important role in immunosenescence, and the practice of "healthy" behavior may minimize the age-associated decline of immune function. The objective of this study was to determine whether exercise, diet, and psychosocial factors were associated with altered immune response to influenza vaccine.

METHODS

Adults aged 62 years and older were categorized into one of three groups: active (> or =20 min vigorous exercise three or more times per week), moderately active (regular exercise but with less intensity, frequency, and/or duration), or sedentary (no exercise). Two weeks postimmunization, serum was frozen for antibody analysis, and peripheral blood mononuclear cells (PBMC) were cultured in vitro with influenza vaccine to elicit antigen-specific responses (proliferation and cytokine [IL-2, IFN-gamma, IL-10] production). Cytokines and antibody were measured by enzyme-linked immunosorbent assay.

RESULTS

The results demonstrated that anti-influenza IgG and IgM were greater in active as compared with moderately active or sedentary participants. PBMC proliferation was lowest in sedentary subjects. Perceived stress was a significant predictor of IL-2. Greater optimism and social activity were associated with greater IL-10. Daily multivitamin intake was significantly correlated with IL-2.

CONCLUSIONS

These results suggest that lifestyle factors including exercise may influence immune response to influenza immunization. The practice of regular, vigorous exercise was associated with enhanced immune response following influenza vaccination in older adults.

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    MeSH

    Aged
    Antibodies, Viral
    Antigens, CD3
    Antigens, CD4
    Antigens, CD8
    Diet
    Exercise
    Humans
    Immunoglobulin M
    Influenza Vaccines
    Influenza, Human
    Interferon-gamma
    Interleukin-10
    Interleukin-2
    Leukocyte Count
    Leukocytes, Mononuclear
    Life Style
    Middle Aged
    Nutritional Physiological Phenomena
    Questionnaires
    Stress, Psychological
    Vaccination

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12196490

    Citation

    TY - JOUR T1 - Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. AU - Kohut,Marian L, AU - Cooper,Megan M, AU - Nickolaus,Michael S, AU - Russell,Dan R, AU - Cunnick,Joan E, PY - 2002/8/28/pubmed PY - 2002/9/24/medline PY - 2002/8/28/entrez SP - M557 EP - 62 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 57 IS - 9 N2 - BACKGROUND: Decreases in immune responsiveness with age contribute to the increased incidence and severity of infectious disease among elderly adults. The immune response to immunization also decreases with advancing age. Lifestyle factors (exercise, diet) have been established to play an important role in immunosenescence, and the practice of "healthy" behavior may minimize the age-associated decline of immune function. The objective of this study was to determine whether exercise, diet, and psychosocial factors were associated with altered immune response to influenza vaccine. METHODS: Adults aged 62 years and older were categorized into one of three groups: active (> or =20 min vigorous exercise three or more times per week), moderately active (regular exercise but with less intensity, frequency, and/or duration), or sedentary (no exercise). Two weeks postimmunization, serum was frozen for antibody analysis, and peripheral blood mononuclear cells (PBMC) were cultured in vitro with influenza vaccine to elicit antigen-specific responses (proliferation and cytokine [IL-2, IFN-gamma, IL-10] production). Cytokines and antibody were measured by enzyme-linked immunosorbent assay. RESULTS: The results demonstrated that anti-influenza IgG and IgM were greater in active as compared with moderately active or sedentary participants. PBMC proliferation was lowest in sedentary subjects. Perceived stress was a significant predictor of IL-2. Greater optimism and social activity were associated with greater IL-10. Daily multivitamin intake was significantly correlated with IL-2. CONCLUSIONS: These results suggest that lifestyle factors including exercise may influence immune response to influenza immunization. The practice of regular, vigorous exercise was associated with enhanced immune response following influenza vaccination in older adults. SN - 1079-5006 UR - https://www.unboundmedicine.com/medline/citation/12196490/full_citation L2 - http://biomedgerontology.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=12196490 ER -