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Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis.
East Mediterr Health J. 2000 Sep-Nov; 6(5-6):926-31.EM

Abstract

The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection (> or = 400 eggs/g of faeces) from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high (community-wide, up to 11/100 infected patients with bleeding). Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution.

Authors+Show Affiliations

Faculty of Medicine, University of Khartoum, Khartoum, Sudan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12197350

Citation

Kheir, M M., et al. "Effects of Single-dose Praziquantel On Morbidity and Mortality Resulting From Intestinal Schistosomiasis." Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, vol. 6, no. 5-6, 2000, pp. 926-31.
Kheir MM, Baraka OZ, el-Tom IA, et al. Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis. East Mediterr Health J. 2000;6(5-6):926-31.
Kheir, M. M., Baraka, O. Z., el-Tom, I. A., Mukhtar, M. M., & Homieda, M. M. (2000). Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis. Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, 6(5-6), 926-31.
Kheir MM, et al. Effects of Single-dose Praziquantel On Morbidity and Mortality Resulting From Intestinal Schistosomiasis. East Mediterr Health J. 2000 Sep-Nov;6(5-6):926-31. PubMed PMID: 12197350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis. AU - Kheir,M M, AU - Baraka,O Z, AU - el-Tom,I A, AU - Mukhtar,M M, AU - Homieda,M M, PY - 2002/8/29/pubmed PY - 2002/9/24/medline PY - 2002/8/29/entrez SP - 926 EP - 31 JF - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JO - East Mediterr Health J VL - 6 IS - 5-6 N2 - The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection (> or = 400 eggs/g of faeces) from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high (community-wide, up to 11/100 infected patients with bleeding). Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution. SN - 1020-3397 UR - https://www.unboundmedicine.com/medline/citation/12197350/Effects_of_single_dose_praziquantel_on_morbidity_and_mortality_resulting_from_intestinal_schistosomiasis_ L2 - http://applications.emro.who.int/emhj/0605_6/EMHJ_2000_6_5-6_926_931.pdf DB - PRIME DP - Unbound Medicine ER -