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Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin.
Am J Clin Nutr. 2002 Sep; 76(3):595-603.AJ

Abstract

BACKGROUND

Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a general population.

OBJECTIVE

The objective was to investigate the associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein, taking into account potential confounders in a population.

DESIGN

Volunteers (n = 376) aged 18-75 y were recruited. In a cross-sectional design, serum (n = 376) and adipose tissue (n = 187) were analyzed for carotenoids, and MP density was measured by spectral fundus reflectance.

RESULTS

Mean MP density in the total study group was 0.33 +/- 0.15. MP density was 13% higher in men than in women (P < 0.05). Serum and blood concentrations of alpha-tocopherol, vitamin C, and all carotenoids except lycopene were significantly higher in women. Adipose lutein concentrations were also significantly higher in women than in men. Regression models showed a positive significant association between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations in men after adjustment for age, but no relation in women. In men, serum lutein remained significantly associated with MP density after adjustment for age, total cholesterol, body mass index, and smoking.

CONCLUSION

The associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations are stronger in men than in women.

Authors+Show Affiliations

TNO Nutrition and Food Research, Zeist, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12198005

Citation

Broekmans, Wendy M R., et al. "Macular Pigment Density in Relation to Serum and Adipose Tissue Concentrations of Lutein and Serum Concentrations of Zeaxanthin." The American Journal of Clinical Nutrition, vol. 76, no. 3, 2002, pp. 595-603.
Broekmans WM, Berendschot TT, Klöpping-Ketelaars IA, et al. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. Am J Clin Nutr. 2002;76(3):595-603.
Broekmans, W. M., Berendschot, T. T., Klöpping-Ketelaars, I. A., de Vries, A. J., Goldbohm, R. A., Tijburg, L. B., Kardinaal, A. F., & van Poppel, G. (2002). Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. The American Journal of Clinical Nutrition, 76(3), 595-603.
Broekmans WM, et al. Macular Pigment Density in Relation to Serum and Adipose Tissue Concentrations of Lutein and Serum Concentrations of Zeaxanthin. Am J Clin Nutr. 2002;76(3):595-603. PubMed PMID: 12198005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. AU - Broekmans,Wendy M R, AU - Berendschot,Tos T J M, AU - Klöpping-Ketelaars,Ineke A A, AU - de Vries,Arjan J, AU - Goldbohm,R Alexandra, AU - Tijburg,Lilian B M, AU - Kardinaal,Alwine F M, AU - van Poppel,Geert, PY - 2002/8/29/pubmed PY - 2002/9/17/medline PY - 2002/8/29/entrez SP - 595 EP - 603 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 76 IS - 3 N2 - BACKGROUND: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a general population. OBJECTIVE: The objective was to investigate the associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein, taking into account potential confounders in a population. DESIGN: Volunteers (n = 376) aged 18-75 y were recruited. In a cross-sectional design, serum (n = 376) and adipose tissue (n = 187) were analyzed for carotenoids, and MP density was measured by spectral fundus reflectance. RESULTS: Mean MP density in the total study group was 0.33 +/- 0.15. MP density was 13% higher in men than in women (P < 0.05). Serum and blood concentrations of alpha-tocopherol, vitamin C, and all carotenoids except lycopene were significantly higher in women. Adipose lutein concentrations were also significantly higher in women than in men. Regression models showed a positive significant association between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations in men after adjustment for age, but no relation in women. In men, serum lutein remained significantly associated with MP density after adjustment for age, total cholesterol, body mass index, and smoking. CONCLUSION: The associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations are stronger in men than in women. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12198005/Macular_pigment_density_in_relation_to_serum_and_adipose_tissue_concentrations_of_lutein_and_serum_concentrations_of_zeaxanthin_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/76.3.595 DB - PRIME DP - Unbound Medicine ER -