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Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: implications for intermittent therapeutic strategies.
J Infect Dis. 2002 Sep 15; 186(6):851-4.JI

Abstract

This study evaluates the change in CD4(+) T cell counts among patients who achieved complete viral suppression and subsequently discontinued highly active antiretroviral therapy (HAART). We included 72 human immunodeficiency virus (HIV)-1-infected patients with plasma HIV RNA loads of <500 copies/mL for at least 3 months who then discontinued therapy for at least 12 weeks. The median CD4(+) T decay while off HAART was 16 cells/mm(3)/month (interquartile range, -6 to -34 cells/month). The mean follow-up after therapy ended was 45 weeks. The slope of the CD4(+) T cell decay was inversely correlated with the increase of CD4(+) T cells while receiving HAART, baseline virus load, CD4(+) T cell count at the time therapy was discontinued, age, and duration HIV RNA levels were undetectable. In a multiple regression analysis model, the increase of CD4(+) T cells while receiving therapy and age were independently associated with the rate of CD4(+) T cell loss.

Authors+Show Affiliations

Washington University School of Medicine, St. Louis, Missouri 63108, USA. tebas@im.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12198623

Citation

Tebas, Pablo, et al. "Effect of Prolonged Discontinuation of Successful Antiretroviral Therapy On CD4+ T Cell Decline in Human Immunodeficiency Virus-infected Patients: Implications for Intermittent Therapeutic Strategies." The Journal of Infectious Diseases, vol. 186, no. 6, 2002, pp. 851-4.
Tebas P, Henry K, Mondy K, et al. Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: implications for intermittent therapeutic strategies. J Infect Dis. 2002;186(6):851-4.
Tebas, P., Henry, K., Mondy, K., Deeks, S., Valdez, H., Cohen, C., & Powderly, W. G. (2002). Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: implications for intermittent therapeutic strategies. The Journal of Infectious Diseases, 186(6), 851-4.
Tebas P, et al. Effect of Prolonged Discontinuation of Successful Antiretroviral Therapy On CD4+ T Cell Decline in Human Immunodeficiency Virus-infected Patients: Implications for Intermittent Therapeutic Strategies. J Infect Dis. 2002 Sep 15;186(6):851-4. PubMed PMID: 12198623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: implications for intermittent therapeutic strategies. AU - Tebas,Pablo, AU - Henry,Keith, AU - Mondy,Kristin, AU - Deeks,Steven, AU - Valdez,Herman, AU - Cohen,Cal, AU - Powderly,William G, Y1 - 2002/08/28/ PY - 2002/03/18/received PY - 2002/05/14/revised PY - 2002/8/29/pubmed PY - 2002/10/17/medline PY - 2002/8/29/entrez SP - 851 EP - 4 JF - The Journal of infectious diseases JO - J Infect Dis VL - 186 IS - 6 N2 - This study evaluates the change in CD4(+) T cell counts among patients who achieved complete viral suppression and subsequently discontinued highly active antiretroviral therapy (HAART). We included 72 human immunodeficiency virus (HIV)-1-infected patients with plasma HIV RNA loads of <500 copies/mL for at least 3 months who then discontinued therapy for at least 12 weeks. The median CD4(+) T decay while off HAART was 16 cells/mm(3)/month (interquartile range, -6 to -34 cells/month). The mean follow-up after therapy ended was 45 weeks. The slope of the CD4(+) T cell decay was inversely correlated with the increase of CD4(+) T cells while receiving HAART, baseline virus load, CD4(+) T cell count at the time therapy was discontinued, age, and duration HIV RNA levels were undetectable. In a multiple regression analysis model, the increase of CD4(+) T cells while receiving therapy and age were independently associated with the rate of CD4(+) T cell loss. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12198623/Effect_of_prolonged_discontinuation_of_successful_antiretroviral_therapy_on_CD4+_T_cell_decline_in_human_immunodeficiency_virus_infected_patients:_implications_for_intermittent_therapeutic_strategies_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/342603 DB - PRIME DP - Unbound Medicine ER -