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Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol.
Hepatology 2002; 36(3):729-36Hep

Abstract

Steatosis has emerged as a histologic finding of importance to the progression of hepatitis C virus (HCV)-associated liver disease. However, most studies of HCV-associated steatosis have excluded alcohol drinkers and individuals with diabetes and thus have not addressed the relative contribution of known causes of steatosis to liver injury in HCV-associated disease. To address this issue, we studied 297 consecutive patients with HCV who met inclusion criteria. Alcohol consumption, demographics, and serologic tests were correlated with degrees of steatosis and fibrosis on liver biopsy. Liver biopsy specimens were also examined for evidence of significant alcohol or nonalcoholic steatohepatitis (NASH) injury. In univariate analysis, steatosis correlated with type 2 diabetes mellitus (P =.005) and body mass index (BMI) (P =.0001) but not with the intensity of alcohol intake (in grams per day). In multivariate analysis, BMI (P =.0002) and genotype 3a infection (P =.02) were independent predictors of steatosis. When patients with risk factors for NASH were excluded, genotype 3a infection was the only independent predictor of steatosis. Steatosis (P =.04) and inflammation (P <.0001) scores on liver biopsy were the only independent predictors of fibrosis. Significant alcohol or NASH injury was found in only 6% of biopsy specimens. In conclusion, steatosis in HCV infection is associated with risk factors for NASH, particularly obesity, rather than alcohol consumption.

Authors+Show Affiliations

Department of Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA. Alexander.Monto@med.va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12198667

Citation

Monto, Alexander, et al. "Steatosis in Chronic Hepatitis C: Relative Contributions of Obesity, Diabetes Mellitus, and Alcohol." Hepatology (Baltimore, Md.), vol. 36, no. 3, 2002, pp. 729-36.
Monto A, Alonzo J, Watson JJ, et al. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology. 2002;36(3):729-36.
Monto, A., Alonzo, J., Watson, J. J., Grunfeld, C., & Wright, T. L. (2002). Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology (Baltimore, Md.), 36(3), pp. 729-36.
Monto A, et al. Steatosis in Chronic Hepatitis C: Relative Contributions of Obesity, Diabetes Mellitus, and Alcohol. Hepatology. 2002;36(3):729-36. PubMed PMID: 12198667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. AU - Monto,Alexander, AU - Alonzo,Judy, AU - Watson,Jessica J, AU - Grunfeld,Carl, AU - Wright,Teresa L, PY - 2002/8/29/pubmed PY - 2002/9/28/medline PY - 2002/8/29/entrez SP - 729 EP - 36 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 36 IS - 3 N2 - Steatosis has emerged as a histologic finding of importance to the progression of hepatitis C virus (HCV)-associated liver disease. However, most studies of HCV-associated steatosis have excluded alcohol drinkers and individuals with diabetes and thus have not addressed the relative contribution of known causes of steatosis to liver injury in HCV-associated disease. To address this issue, we studied 297 consecutive patients with HCV who met inclusion criteria. Alcohol consumption, demographics, and serologic tests were correlated with degrees of steatosis and fibrosis on liver biopsy. Liver biopsy specimens were also examined for evidence of significant alcohol or nonalcoholic steatohepatitis (NASH) injury. In univariate analysis, steatosis correlated with type 2 diabetes mellitus (P =.005) and body mass index (BMI) (P =.0001) but not with the intensity of alcohol intake (in grams per day). In multivariate analysis, BMI (P =.0002) and genotype 3a infection (P =.02) were independent predictors of steatosis. When patients with risk factors for NASH were excluded, genotype 3a infection was the only independent predictor of steatosis. Steatosis (P =.04) and inflammation (P <.0001) scores on liver biopsy were the only independent predictors of fibrosis. Significant alcohol or NASH injury was found in only 6% of biopsy specimens. In conclusion, steatosis in HCV infection is associated with risk factors for NASH, particularly obesity, rather than alcohol consumption. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/12198667/Steatosis_in_chronic_hepatitis_C:_relative_contributions_of_obesity_diabetes_mellitus_and_alcohol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270913902000800 DB - PRIME DP - Unbound Medicine ER -