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NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC).
Acta Neuropathol. 2002 Oct; 104(4):333-41.AN

Abstract

Diffuse neurofibrillary tangles with calcification (DNTC) is a rare tangle-predominant dementia, as well as one of the tauopathies lacking Abeta deposition. It is characterized by temporo-frontal lobar atrophy, Fahr-type calcification and, histopathologically, numerous neurofibrillary tangles in the limbic system and neocortex. Recently, accumulation of alpha-synuclein (alphaS), the precursor of the non-beta amyloid component (NAC) of Alzheimer's disease, has been shown in diverse neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, Alzheimer's disease, multiple system atrophy and parkinsonism-dementia complex of Guam. To clarify whether alphaS accumulates in other neurodegenerative disorders, we investigated eight DNTC brains using immunohistochemistry and demonstrated remarkable alphaS deposition in the neurons and astrocytes in many anatomical regions. Abundant Lewy bodies were observed in the amygdala (seven cases) and hippocampus (seven cases), and, to a lesser degree, in the substantia nigra (six cases) and dorsal vagal nucleus (five cases). In the hippocampus, many Lewy neurites were distributed in the stratum oriens and stratum pyramidale in the CA2-3 and the subiculum. Furthermore, numerous NAC-positive astrocytes were detected in the hippocampus and temporal cortex. This investigation reveals that neurons and astrocytes are extensively involved in remarkable alphaS pathology in the DNTC brain, and that the alphaS pathology compounds the cardinal pathological features of tau pathology. These findings suggest that (1) DNTC shares a common pathophysiological background with Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy in which abnormal alphaS aggregation is observed, and (2) there is an interaction between alphaS and tau pathology that does not involve amyloid in DNTC.

Authors+Show Affiliations

Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. terada_1@cc.okayama-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12200618

Citation

Yokota, Osamu, et al. "NACP/alpha-synuclein Immunoreactivity in Diffuse Neurofibrillary Tangles With Calcification (DNTC)." Acta Neuropathologica, vol. 104, no. 4, 2002, pp. 333-41.
Yokota O, Terada S, Ishizu H, et al. NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). Acta Neuropathol. 2002;104(4):333-41.
Yokota, O., Terada, S., Ishizu, H., Tsuchiya, K., Kitamura, Y., Ikeda, K., Uéda, K., & Kuroda, S. (2002). NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). Acta Neuropathologica, 104(4), 333-41.
Yokota O, et al. NACP/alpha-synuclein Immunoreactivity in Diffuse Neurofibrillary Tangles With Calcification (DNTC). Acta Neuropathol. 2002;104(4):333-41. PubMed PMID: 12200618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). AU - Yokota,Osamu, AU - Terada,Seishi, AU - Ishizu,Hideki, AU - Tsuchiya,Kuniaki, AU - Kitamura,Yoshihiro, AU - Ikeda,Kenji, AU - Uéda,Kenji, AU - Kuroda,Shigetoshi, Y1 - 2002/05/08/ PY - 2002/01/15/received PY - 2002/03/14/accepted PY - 2002/8/30/pubmed PY - 2002/12/28/medline PY - 2002/8/30/entrez SP - 333 EP - 41 JF - Acta neuropathologica JO - Acta Neuropathol VL - 104 IS - 4 N2 - Diffuse neurofibrillary tangles with calcification (DNTC) is a rare tangle-predominant dementia, as well as one of the tauopathies lacking Abeta deposition. It is characterized by temporo-frontal lobar atrophy, Fahr-type calcification and, histopathologically, numerous neurofibrillary tangles in the limbic system and neocortex. Recently, accumulation of alpha-synuclein (alphaS), the precursor of the non-beta amyloid component (NAC) of Alzheimer's disease, has been shown in diverse neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, Alzheimer's disease, multiple system atrophy and parkinsonism-dementia complex of Guam. To clarify whether alphaS accumulates in other neurodegenerative disorders, we investigated eight DNTC brains using immunohistochemistry and demonstrated remarkable alphaS deposition in the neurons and astrocytes in many anatomical regions. Abundant Lewy bodies were observed in the amygdala (seven cases) and hippocampus (seven cases), and, to a lesser degree, in the substantia nigra (six cases) and dorsal vagal nucleus (five cases). In the hippocampus, many Lewy neurites were distributed in the stratum oriens and stratum pyramidale in the CA2-3 and the subiculum. Furthermore, numerous NAC-positive astrocytes were detected in the hippocampus and temporal cortex. This investigation reveals that neurons and astrocytes are extensively involved in remarkable alphaS pathology in the DNTC brain, and that the alphaS pathology compounds the cardinal pathological features of tau pathology. These findings suggest that (1) DNTC shares a common pathophysiological background with Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy in which abnormal alphaS aggregation is observed, and (2) there is an interaction between alphaS and tau pathology that does not involve amyloid in DNTC. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/12200618/NACP/alpha_synuclein_immunoreactivity_in_diffuse_neurofibrillary_tangles_with_calcification__DNTC__ L2 - https://dx.doi.org/10.1007/s00401-002-0545-5 DB - PRIME DP - Unbound Medicine ER -