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Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women.
Calcif Tissue Int. 2002 Oct; 71(4):323-8.CT

Abstract

Insulin-like growth factor-1 (IGF-I) plays a central role in the maintenance of bone mass. To test whether two major IGF-I binding proteins, IGFBP-4 and IGFBP-5, are related to bone mineral density (BMD), we studied a sample of the Framingham Offspring Cohort participants (99 men and 101 women, ages 60-87). Serum levels of IGF-I, IGFBP-4, and IGFBP-5 were measured by previously validated radioimmunoassays (CVs approximately 10%). BMDs of the proximal femur and lumbar spine were measured using a Lunar DPX-L densitometer. In males, but not females, IGF-I and IGFBP-5 were inversely associated with age (r = 0.34 and r = -0.28, respectively; P <0.01), while IGFBP-4 levels were positively associated with age (P <0.01). Multivariate means for BMD (adjusted for age, body mass index, height, smoking, and in women, estrogen use) were computed across quartiles of IGFBP-4 and IGFBP-5 and IGFBP-4/IGFBP-5 ratio. In women, but not men, IGFBP-5 was positively associated with femoral neck BMD (P = 0.03), however, after statistical adjustment for IGF-I, this association was no longer significant. No other associations were observed for BMD at any other site. Further study is necessary for elucidation of the gender differences in the possible influence of IGF system components on bone mass.

Authors+Show Affiliations

Hebrew Rehabilitation Center for Aged, Research and Training Institute and Harvard Medical School Division on Aging, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12202958

Citation

Karasik, D, et al. "Insulin-like Growth Factor Binding Proteins 4 and 5 and Bone Mineral Density in Elderly Men and Women." Calcified Tissue International, vol. 71, no. 4, 2002, pp. 323-8.
Karasik D, Rosen CJ, Hannan MT, et al. Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women. Calcif Tissue Int. 2002;71(4):323-8.
Karasik, D., Rosen, C. J., Hannan, M. T., Broe, K. E., Dawson-Hughes, B., Gagnon, D. R., Wilson, P. W., Visser, M., Langlois, J. A., Mohan, S., & Kiel, D. P. (2002). Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women. Calcified Tissue International, 71(4), 323-8.
Karasik D, et al. Insulin-like Growth Factor Binding Proteins 4 and 5 and Bone Mineral Density in Elderly Men and Women. Calcif Tissue Int. 2002;71(4):323-8. PubMed PMID: 12202958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women. AU - Karasik,D, AU - Rosen,C J, AU - Hannan,M T, AU - Broe,K E, AU - Dawson-Hughes,B, AU - Gagnon,D R, AU - Wilson,P W F, AU - Visser,M, AU - Langlois,J A, AU - Mohan,S, AU - Kiel,D P, Y1 - 2002/09/04/ PY - 2002/01/08/received PY - 2002/03/27/accepted PY - 2002/8/31/pubmed PY - 2003/3/5/medline PY - 2002/8/31/entrez SP - 323 EP - 8 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 71 IS - 4 N2 - Insulin-like growth factor-1 (IGF-I) plays a central role in the maintenance of bone mass. To test whether two major IGF-I binding proteins, IGFBP-4 and IGFBP-5, are related to bone mineral density (BMD), we studied a sample of the Framingham Offspring Cohort participants (99 men and 101 women, ages 60-87). Serum levels of IGF-I, IGFBP-4, and IGFBP-5 were measured by previously validated radioimmunoassays (CVs approximately 10%). BMDs of the proximal femur and lumbar spine were measured using a Lunar DPX-L densitometer. In males, but not females, IGF-I and IGFBP-5 were inversely associated with age (r = 0.34 and r = -0.28, respectively; P <0.01), while IGFBP-4 levels were positively associated with age (P <0.01). Multivariate means for BMD (adjusted for age, body mass index, height, smoking, and in women, estrogen use) were computed across quartiles of IGFBP-4 and IGFBP-5 and IGFBP-4/IGFBP-5 ratio. In women, but not men, IGFBP-5 was positively associated with femoral neck BMD (P = 0.03), however, after statistical adjustment for IGF-I, this association was no longer significant. No other associations were observed for BMD at any other site. Further study is necessary for elucidation of the gender differences in the possible influence of IGF system components on bone mass. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/12202958/Insulin_like_growth_factor_binding_proteins_4_and_5_and_bone_mineral_density_in_elderly_men_and_women_ L2 - https://dx.doi.org/10.1007/s00223-002-1002-0 DB - PRIME DP - Unbound Medicine ER -