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In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo-planar imaging.
J Magn Reson Imaging. 2002 Aug; 16(2):196-200.JM

Abstract

PURPOSE

To measure for the first time the apparent diffusion coefficient (ADC) values in anatomical regions of the prostate for normal and patient groups, and to investigate its use as a differentiating parameter between healthy and malignant tissue within the patient group.

MATERIALS AND METHODS

Single-shot diffusion-weighted echo-planar imaging (DW-EPI) was used to measure the ADC in the prostate in normal (N = 7) and patient (N = 19) groups. The spin-echo images comprised 96 x 96 pixels (field of view of 16 cm, TR/TE = 4000/120 msec) with six b-factor values ranging from 64 to 786 seconds/mm(2).

RESULTS

The ADC values averaged over all patients in non-cancerous and malignant peripheral zone (PZ) tissues were 1.82 +/- 0.53 x 10(-3) (mean +/- SD) and 1.38 +/- 0.52 x 10(-3) mm(2)/second, respectively (P = 0.00045, N = 17, paired t-test). The ADC values were found to be higher in the non-cancerous PZ (1.88 +/- 0.48 x 10(-3)) than in healthy or benign prostatic hyperplasia central gland (BPH-CG) region (1.62 +/- 0.41 x 10(-3)). For the normal group, the mean values were 1.91 +/- 0.46 x 10(-3) and 1.63 +/- 0.30 x 10(-3) mm(2)/second for the PZ and CG, respectively (P = 0.011, N = 7). Significant overlap exists between individual values among all tissue types. Furthermore, ADC values for the same tissue type showed no statistically significant difference between the two subject groups.

CONCLUSION

ADC is quantified in the prostate using DW-EPI. Values are lower in cancerous than in healthy PZ in patients, and in BPH-CG than PZ in volunteers.

Authors+Show Affiliations

Centre for MRI, Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, England. B.Issa@uaeu.ac.ae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12203768

Citation

Issa, Bashar. "In Vivo Measurement of the Apparent Diffusion Coefficient in Normal and Malignant Prostatic Tissues Using Echo-planar Imaging." Journal of Magnetic Resonance Imaging : JMRI, vol. 16, no. 2, 2002, pp. 196-200.
Issa B. In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo-planar imaging. J Magn Reson Imaging. 2002;16(2):196-200.
Issa, B. (2002). In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo-planar imaging. Journal of Magnetic Resonance Imaging : JMRI, 16(2), 196-200.
Issa B. In Vivo Measurement of the Apparent Diffusion Coefficient in Normal and Malignant Prostatic Tissues Using Echo-planar Imaging. J Magn Reson Imaging. 2002;16(2):196-200. PubMed PMID: 12203768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo-planar imaging. A1 - Issa,Bashar, PY - 2002/8/31/pubmed PY - 2002/12/10/medline PY - 2002/8/31/entrez SP - 196 EP - 200 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 16 IS - 2 N2 - PURPOSE: To measure for the first time the apparent diffusion coefficient (ADC) values in anatomical regions of the prostate for normal and patient groups, and to investigate its use as a differentiating parameter between healthy and malignant tissue within the patient group. MATERIALS AND METHODS: Single-shot diffusion-weighted echo-planar imaging (DW-EPI) was used to measure the ADC in the prostate in normal (N = 7) and patient (N = 19) groups. The spin-echo images comprised 96 x 96 pixels (field of view of 16 cm, TR/TE = 4000/120 msec) with six b-factor values ranging from 64 to 786 seconds/mm(2). RESULTS: The ADC values averaged over all patients in non-cancerous and malignant peripheral zone (PZ) tissues were 1.82 +/- 0.53 x 10(-3) (mean +/- SD) and 1.38 +/- 0.52 x 10(-3) mm(2)/second, respectively (P = 0.00045, N = 17, paired t-test). The ADC values were found to be higher in the non-cancerous PZ (1.88 +/- 0.48 x 10(-3)) than in healthy or benign prostatic hyperplasia central gland (BPH-CG) region (1.62 +/- 0.41 x 10(-3)). For the normal group, the mean values were 1.91 +/- 0.46 x 10(-3) and 1.63 +/- 0.30 x 10(-3) mm(2)/second for the PZ and CG, respectively (P = 0.011, N = 7). Significant overlap exists between individual values among all tissue types. Furthermore, ADC values for the same tissue type showed no statistically significant difference between the two subject groups. CONCLUSION: ADC is quantified in the prostate using DW-EPI. Values are lower in cancerous than in healthy PZ in patients, and in BPH-CG than PZ in volunteers. SN - 1053-1807 UR - https://www.unboundmedicine.com/medline/citation/12203768/In_vivo_measurement_of_the_apparent_diffusion_coefficient_in_normal_and_malignant_prostatic_tissues_using_echo_planar_imaging_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1053-1807&date=2002&volume=16&issue=2&spage=196 DB - PRIME DP - Unbound Medicine ER -