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Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud.
Mech Dev. 2002 Sep; 117(1-2):331-5.MD

Abstract

The development of skeletal muscle in vertebrate embryos is controlled by a transcriptional cascade involving the four myogenic regulatory factors. In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD. We have re-examined the expression pattern of Mrf4 and show that in the hypaxial domain of thoracic somites (the somitic bud) Mrf4 expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis.

Authors+Show Affiliations

Summerbell D
Division of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
Halai C
No affiliation info available
Rigby PW
No affiliation info available

MeSH

AnimalsDNA-Binding ProteinsGene Expression Regulation, DevelopmentalIn Situ HybridizationMiceMice, Inbred C57BLMice, Inbred CBAMuscle DevelopmentMuscle ProteinsMuscle, SkeletalMyogenic Regulatory Factor 5Myogenic Regulatory FactorsMyogeninSomitesTrans-Activators

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12204280

Citation

Summerbell, Dennis, et al. "Expression of the Myogenic Regulatory Factor Mrf4 Precedes or Is Contemporaneous With That of Myf5 in the Somitic Bud." Mechanisms of Development, vol. 117, no. 1-2, 2002, pp. 331-5.
Summerbell D, Halai C, Rigby PW. Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud. Mech Dev. 2002;117(1-2):331-5.
Summerbell, D., Halai, C., & Rigby, P. W. (2002). Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud. Mechanisms of Development, 117(1-2), 331-5.
Summerbell D, Halai C, Rigby PW. Expression of the Myogenic Regulatory Factor Mrf4 Precedes or Is Contemporaneous With That of Myf5 in the Somitic Bud. Mech Dev. 2002;117(1-2):331-5. PubMed PMID: 12204280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud. AU - Summerbell,Dennis, AU - Halai,Chandrika, AU - Rigby,Peter W J, PY - 2002/9/3/pubmed PY - 2003/4/10/medline PY - 2002/9/3/entrez SP - 331 EP - 5 JF - Mechanisms of development JO - Mech Dev VL - 117 IS - 1-2 N2 - The development of skeletal muscle in vertebrate embryos is controlled by a transcriptional cascade involving the four myogenic regulatory factors. In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD. We have re-examined the expression pattern of Mrf4 and show that in the hypaxial domain of thoracic somites (the somitic bud) Mrf4 expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis. SN - 0925-4773 UR - https://www.unboundmedicine.com/medline/citation/12204280/Expression_of_the_myogenic_regulatory_factor_Mrf4_precedes_or_is_contemporaneous_with_that_of_Myf5_in_the_somitic_bud_ DB - PRIME DP - Unbound Medicine ER -