Tags

Type your tag names separated by a space and hit enter

[Role of nitric oxide in pathogenesis of pregnancy induced hypertension].
Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28; 25(4):354-6.HY

Abstract

OBJECTIVE

We attempted to investigate the role of nitric oxide(NO) in pathogenesis of pregnancy-induced hypertension(PIH).

METHODS

No-nitro-L-arginine-methyl ester(L-NAME) was used to inhibit nitric oxide synthase(NOS) in pregnant rats. Indices including blood pressure, urine protein concentration, pup weight, serum NO level and plasma ET-1 level were measured. Nitroglycerin, a nitric oxide donor, was used to observe its impact on the effect of L-NAME at the same time.

RESULTS

Infusion of L-NAME elevated blood pressure, increased urine protein concentration, decreased pup weight, decreased serum NO level and raised plasma ET-1 level(P < 0.01, respectively); However in the L-NAME-treated animals nitroglycerin significantly lowered blood pressure, decreased urine protein concentration, increased pup weight, increased serum NO level and decreased plasma ET-1 level(P < 0.01, respectively).

CONCLUSIONS

1. Infusion of L-NAME, an inhibitor of NOS, causes decreased serum NO level and some signs similar to preeclampsia such as hypertension, proteinuria and intrauterine growth retardation(IUGR). Nitroglycerin can reverse the lesions induced by the treatment of L-NAME. These findings indicate that reduced level of NO may be a factor responsible for PIH. 2. NO can decrease the plasma ET-1 level. NO may regulate the process of PIH via ET-1 pathway. It may be one mechanism for NO. 3. An useful animal model for PIH is provided to test novel therapeutic and preventive strategies.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12206000

Citation

Wang, C H., et al. "[Role of Nitric Oxide in Pathogenesis of Pregnancy Induced Hypertension]." Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, vol. 25, no. 4, 2000, pp. 354-6.
Wang CH, Li ZY, Xiao GX. [Role of nitric oxide in pathogenesis of pregnancy induced hypertension]. Hunan Yi Ke Da Xue Xue Bao. 2000;25(4):354-6.
Wang, C. H., Li, Z. Y., & Xiao, G. X. (2000). [Role of nitric oxide in pathogenesis of pregnancy induced hypertension]. Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, 25(4), 354-6.
Wang CH, Li ZY, Xiao GX. [Role of Nitric Oxide in Pathogenesis of Pregnancy Induced Hypertension]. Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28;25(4):354-6. PubMed PMID: 12206000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of nitric oxide in pathogenesis of pregnancy induced hypertension]. AU - Wang,C H, AU - Li,Z Y, AU - Xiao,G X, PY - 2002/9/11/pubmed PY - 2003/2/7/medline PY - 2002/9/11/entrez SP - 354 EP - 6 JF - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University JO - Hunan Yi Ke Da Xue Xue Bao VL - 25 IS - 4 N2 - OBJECTIVE: We attempted to investigate the role of nitric oxide(NO) in pathogenesis of pregnancy-induced hypertension(PIH). METHODS: No-nitro-L-arginine-methyl ester(L-NAME) was used to inhibit nitric oxide synthase(NOS) in pregnant rats. Indices including blood pressure, urine protein concentration, pup weight, serum NO level and plasma ET-1 level were measured. Nitroglycerin, a nitric oxide donor, was used to observe its impact on the effect of L-NAME at the same time. RESULTS: Infusion of L-NAME elevated blood pressure, increased urine protein concentration, decreased pup weight, decreased serum NO level and raised plasma ET-1 level(P < 0.01, respectively); However in the L-NAME-treated animals nitroglycerin significantly lowered blood pressure, decreased urine protein concentration, increased pup weight, increased serum NO level and decreased plasma ET-1 level(P < 0.01, respectively). CONCLUSIONS: 1. Infusion of L-NAME, an inhibitor of NOS, causes decreased serum NO level and some signs similar to preeclampsia such as hypertension, proteinuria and intrauterine growth retardation(IUGR). Nitroglycerin can reverse the lesions induced by the treatment of L-NAME. These findings indicate that reduced level of NO may be a factor responsible for PIH. 2. NO can decrease the plasma ET-1 level. NO may regulate the process of PIH via ET-1 pathway. It may be one mechanism for NO. 3. An useful animal model for PIH is provided to test novel therapeutic and preventive strategies. SN - 1000-5625 UR - https://www.unboundmedicine.com/medline/citation/12206000/[Role_of_nitric_oxide_in_pathogenesis_of_pregnancy_induced_hypertension]_ DB - PRIME DP - Unbound Medicine ER -