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Optimal age for measles vaccination.
J Indian Med Assoc. 2002 Jan; 100(1):24-6.JI

Abstract

Children in the age groups of 6-9 (group I) and >9-12 months (group II, control) 75 in each group, sex-matched were studied for antimeasles antibodies IgG and IgM by ELISA technique, before immunisation with Schwarz strain of measles vaccine. IgG antibodies were found in 66% in group I and none in group II, indicating the waning of maternal antibodies at an early age which come down before 6 months of age. After administration of measles vaccine to both the groups seroconversion was estimated at intervals of 4 weeks and 6 months after vaccination. Antimeasles IgM antibodies increased after vaccination and decreased 6 months after vaccination in both groups. Antimeasles IgG antibodies showed a significant increase in both groups. Increase was high in group II. This shows that anti-IgG antibodies to measles increased with age. The study shows the disappearance of protective level of immunisation at an early age. Seroconversion following vaccination at the age of 6 months is low, and hence a booster dose is recommended at 15 months.

Authors+Show Affiliations

Vidyashankar C
Department of Paediatrics, Armed Force Medical College, Pune.

MeSH

Age FactorsAntibodies, ViralEnzyme-Linked Immunosorbent AssayFemaleHumansImmunization, SecondaryImmunoglobulin GImmunoglobulin MInfantMaleMeaslesMeasles Vaccine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12206338

Citation

Vidyashankar, C. "Optimal Age for Measles Vaccination." Journal of the Indian Medical Association, vol. 100, no. 1, 2002, pp. 24-6.
Vidyashankar C. Optimal age for measles vaccination. J Indian Med Assoc. 2002;100(1):24-6.
Vidyashankar, C. (2002). Optimal age for measles vaccination. Journal of the Indian Medical Association, 100(1), 24-6.
Vidyashankar C. Optimal Age for Measles Vaccination. J Indian Med Assoc. 2002;100(1):24-6. PubMed PMID: 12206338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimal age for measles vaccination. A1 - Vidyashankar,C, PY - 2002/9/11/pubmed PY - 2002/11/26/medline PY - 2002/9/11/entrez SP - 24 EP - 6 JF - Journal of the Indian Medical Association JO - J Indian Med Assoc VL - 100 IS - 1 N2 - Children in the age groups of 6-9 (group I) and >9-12 months (group II, control) 75 in each group, sex-matched were studied for antimeasles antibodies IgG and IgM by ELISA technique, before immunisation with Schwarz strain of measles vaccine. IgG antibodies were found in 66% in group I and none in group II, indicating the waning of maternal antibodies at an early age which come down before 6 months of age. After administration of measles vaccine to both the groups seroconversion was estimated at intervals of 4 weeks and 6 months after vaccination. Antimeasles IgM antibodies increased after vaccination and decreased 6 months after vaccination in both groups. Antimeasles IgG antibodies showed a significant increase in both groups. Increase was high in group II. This shows that anti-IgG antibodies to measles increased with age. The study shows the disappearance of protective level of immunisation at an early age. Seroconversion following vaccination at the age of 6 months is low, and hence a booster dose is recommended at 15 months. SN - 0019-5847 UR - https://www.unboundmedicine.com/medline/citation/12206338/Optimal_age_for_measles_vaccination_ DB - PRIME DP - Unbound Medicine ER -