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Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania.
Horm Res 2002; 58(2):78-82HR

Abstract

OBJECTIVE

To evaluate the long-term efficacy and possible side effects of low doses of iodized oil on iodine nutrition and thyroid function in endemic goiter in Romania.

METHODS

Random selection of 214 schoolchildren aged 6-14 years. Serial measurements of urinary iodine, thyroid volume with ultrasound, serum concentrations of thyrotropin, free thyroxine, thyroglobulin and thyroid autoantibodies before and up to 2 years after the oral administration of 200 mg iodine in iodized oil.

RESULTS

Urinary iodine concentrations indicated a moderate iodine deficiency before therapy, sharply increased soon after therapy and slowly decreased thereafter but remained within the normal range up to more than 1 year after therapy. The prevalence of goiter was 29% before the administration of iodized oil and 9% 1 year later. Thyroid function tests and autoantibodies were normal before and up to 2 years after therapy.

CONCLUSION

A single dose of 200 mg iodine from oral Lipiodol appears adequate and safe for correcting moderate iodine deficiency in children.

Authors+Show Affiliations

Institute of Endocrinology, Bucharest, Romania.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12207166

Citation

Simescu, M, et al. "Iodized Oil as a Complement to Iodized Salt in Schoolchildren in Endemic Goiter in Romania." Hormone Research, vol. 58, no. 2, 2002, pp. 78-82.
Simescu M, Varciu M, Nicolaescu E, et al. Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. Horm Res. 2002;58(2):78-82.
Simescu, M., Varciu, M., Nicolaescu, E., Gnat, D., Podoba, J., Mihaescu, M., & Delange, F. (2002). Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. Hormone Research, 58(2), pp. 78-82.
Simescu M, et al. Iodized Oil as a Complement to Iodized Salt in Schoolchildren in Endemic Goiter in Romania. Horm Res. 2002;58(2):78-82. PubMed PMID: 12207166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. AU - Simescu,M, AU - Varciu,M, AU - Nicolaescu,E, AU - Gnat,D, AU - Podoba,J, AU - Mihaescu,M, AU - Delange,F, PY - 2002/9/11/pubmed PY - 2003/2/7/medline PY - 2002/9/11/entrez SP - 78 EP - 82 JF - Hormone research JO - Horm. Res. VL - 58 IS - 2 N2 - OBJECTIVE: To evaluate the long-term efficacy and possible side effects of low doses of iodized oil on iodine nutrition and thyroid function in endemic goiter in Romania. METHODS: Random selection of 214 schoolchildren aged 6-14 years. Serial measurements of urinary iodine, thyroid volume with ultrasound, serum concentrations of thyrotropin, free thyroxine, thyroglobulin and thyroid autoantibodies before and up to 2 years after the oral administration of 200 mg iodine in iodized oil. RESULTS: Urinary iodine concentrations indicated a moderate iodine deficiency before therapy, sharply increased soon after therapy and slowly decreased thereafter but remained within the normal range up to more than 1 year after therapy. The prevalence of goiter was 29% before the administration of iodized oil and 9% 1 year later. Thyroid function tests and autoantibodies were normal before and up to 2 years after therapy. CONCLUSION: A single dose of 200 mg iodine from oral Lipiodol appears adequate and safe for correcting moderate iodine deficiency in children. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/12207166/Iodized_oil_as_a_complement_to_iodized_salt_in_schoolchildren_in_endemic_goiter_in_Romania_ L2 - https://www.karger.com?DOI=10.1159/000064657 DB - PRIME DP - Unbound Medicine ER -