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Current concepts in radiation enteritis and implications for future clinical trials.
Cancer 2002; 95(5):1151-63C

Abstract

BACKGROUND

Radiation enteritis is one of the most feared complications of abdominal and pelvic radiation. Once its occurs, the process is relentless and may result in the patient's death. Available treatment is only supportive. Recent progress in molecular biology has shed some light on the pathogenesis of radiation enteritis and other diseases that are characterized by excessive fibrosis. New treatment modalities may be devised to improve the outcome of patients who are affected with this complication.

METHODS

A literature search was used to identify the common denominator between many radiation-induced fibrotic conditions and other sclerotic diseases. Factors that affect the disease process and possible therapeutic interventions were evaluated.

RESULTS

The hyperstimulation of transforming growth factor beta1 (TGF-beta1) leads to increased fibrosis and, ultimately, organ failure. Interferon gamma (IFN-gamma) inhibits the effects of TGF-beta1 in the nucleus. The fibrotic process may be reverted by IFN-gamma in various pathologic conditions.

CONCLUSIONS

Radiation enteritis and other radiation-induced, long-term complications are characterized by excessive stimulation of TGF-beta1. Preliminary studies suggest that IFN-gamma may be effective in the treatment of patients with radiation-induced cutaneous fibrosis. IFN-gamma should be considered in Phase I-II studies to assess its toxicity and efficacy in the treatment of patients with radiation enteritis.

Authors+Show Affiliations

Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 75216, USA. namphong.nguyen@med.va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12209703

Citation

Nguyen, Nam P., et al. "Current Concepts in Radiation Enteritis and Implications for Future Clinical Trials." Cancer, vol. 95, no. 5, 2002, pp. 1151-63.
Nguyen NP, Antoine JE, Dutta S, et al. Current concepts in radiation enteritis and implications for future clinical trials. Cancer. 2002;95(5):1151-63.
Nguyen, N. P., Antoine, J. E., Dutta, S., Karlsson, U., & Sallah, S. (2002). Current concepts in radiation enteritis and implications for future clinical trials. Cancer, 95(5), pp. 1151-63.
Nguyen NP, et al. Current Concepts in Radiation Enteritis and Implications for Future Clinical Trials. Cancer. 2002 Sep 1;95(5):1151-63. PubMed PMID: 12209703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current concepts in radiation enteritis and implications for future clinical trials. AU - Nguyen,Nam P, AU - Antoine,John E, AU - Dutta,Suresh, AU - Karlsson,Ulf, AU - Sallah,Sabah, PY - 2002/9/5/pubmed PY - 2002/9/18/medline PY - 2002/9/5/entrez SP - 1151 EP - 63 JF - Cancer JO - Cancer VL - 95 IS - 5 N2 - BACKGROUND: Radiation enteritis is one of the most feared complications of abdominal and pelvic radiation. Once its occurs, the process is relentless and may result in the patient's death. Available treatment is only supportive. Recent progress in molecular biology has shed some light on the pathogenesis of radiation enteritis and other diseases that are characterized by excessive fibrosis. New treatment modalities may be devised to improve the outcome of patients who are affected with this complication. METHODS: A literature search was used to identify the common denominator between many radiation-induced fibrotic conditions and other sclerotic diseases. Factors that affect the disease process and possible therapeutic interventions were evaluated. RESULTS: The hyperstimulation of transforming growth factor beta1 (TGF-beta1) leads to increased fibrosis and, ultimately, organ failure. Interferon gamma (IFN-gamma) inhibits the effects of TGF-beta1 in the nucleus. The fibrotic process may be reverted by IFN-gamma in various pathologic conditions. CONCLUSIONS: Radiation enteritis and other radiation-induced, long-term complications are characterized by excessive stimulation of TGF-beta1. Preliminary studies suggest that IFN-gamma may be effective in the treatment of patients with radiation-induced cutaneous fibrosis. IFN-gamma should be considered in Phase I-II studies to assess its toxicity and efficacy in the treatment of patients with radiation enteritis. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12209703/Current_concepts_in_radiation_enteritis_and_implications_for_future_clinical_trials_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0008-543X&date=2002&volume=95&issue=5&spage=1151 DB - PRIME DP - Unbound Medicine ER -