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Small-fiber neuropathy.
Muscle Nerve. 2002 Aug; 26(2):173-88.MN

Abstract

Small-fiber neuropathy is a common disorder. It is often "idiopathic" and typically presents with painful feet in patients over the age of 60. Autoimmune mechanisms are often suspected, but rarely identified. Known causes of small-fiber neuropathy include diabetes mellitus, amyloidosis, toxins, and inherited sensory and autonomic neuropathies. Occasionally, small-fiber neuropathy is diffuse or multifocal. Depending on the type of small-fiber neuropathy, autonomic dysfunction can be significant or subclinical. Diagnosis is made on the basis of the clinical features, normal nerve conduction studies, and abnormal specialized tests of small-fiber function. These specialized studies include assessment of epidermal nerve fiber density as well as sudomotor, quantitative sensory, and cardiovagal testing. The sensitivities of these tests range from 59-88%. Each has certain advantages and disadvantages, and the tests may be complementary. Unless an underlying disease is identified, treatment is usually directed toward alleviation of neuropathic pain.

Authors+Show Affiliations

Department of Neurology, University of Pittsburgh School of Medicine, UPMC Presbyterian, 200 Lothrop Street, F878, Pittsburgh, Pennsylvania 15213, USA. lacomis@np.awing.upmc.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12210380

Citation

Lacomis, David. "Small-fiber Neuropathy." Muscle & Nerve, vol. 26, no. 2, 2002, pp. 173-88.
Lacomis D. Small-fiber neuropathy. Muscle Nerve. 2002;26(2):173-88.
Lacomis, D. (2002). Small-fiber neuropathy. Muscle & Nerve, 26(2), 173-88.
Lacomis D. Small-fiber Neuropathy. Muscle Nerve. 2002;26(2):173-88. PubMed PMID: 12210380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small-fiber neuropathy. A1 - Lacomis,David, PY - 2002/9/5/pubmed PY - 2002/9/20/medline PY - 2002/9/5/entrez SP - 173 EP - 88 JF - Muscle & nerve JO - Muscle Nerve VL - 26 IS - 2 N2 - Small-fiber neuropathy is a common disorder. It is often "idiopathic" and typically presents with painful feet in patients over the age of 60. Autoimmune mechanisms are often suspected, but rarely identified. Known causes of small-fiber neuropathy include diabetes mellitus, amyloidosis, toxins, and inherited sensory and autonomic neuropathies. Occasionally, small-fiber neuropathy is diffuse or multifocal. Depending on the type of small-fiber neuropathy, autonomic dysfunction can be significant or subclinical. Diagnosis is made on the basis of the clinical features, normal nerve conduction studies, and abnormal specialized tests of small-fiber function. These specialized studies include assessment of epidermal nerve fiber density as well as sudomotor, quantitative sensory, and cardiovagal testing. The sensitivities of these tests range from 59-88%. Each has certain advantages and disadvantages, and the tests may be complementary. Unless an underlying disease is identified, treatment is usually directed toward alleviation of neuropathic pain. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/12210380/Small_fiber_neuropathy_ L2 - https://doi.org/10.1002/mus.10181 DB - PRIME DP - Unbound Medicine ER -
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