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Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus.
Ann Neurol. 2002 Aug; 52(2):240-3.AN

Abstract

Deep-brain stimulation of the subthalamic nucleus appears to reduce levodopa-induced dyskinesias, but whether this effect is caused by the reduction of the total levodopa ingestion or represents a direct effect on the motor system is unknown. Precision grip force of grasping movements and levodopa-induced dyskinesias was analyzed in 10 parkinsonian patients before and after 3 months of deep-brain stimulation of the subthalamic nucleus. Peak grip force was abnormally increased before surgery in the off-drug state and, particularly, in the on-drug state (sensitization). This grip force upregulation normalized with chronic deep-brain stimulation in both conditions (desensitization). Peak-dose dyskinesias also improved, and off-dystonia was completely abolished. Mean dosage of dopaminergic drugs was reduced, but force overflow and dyskinesias were equally improved in 2 patients without a reduction. Despite the same single levodopa test dose, force excess and levodopa-induced dyskinesias were drastically reduced after 3 months of deep-brain stimulation of the subthalamic nucleus. This indicates that direct effects of deep-brain stimulation of the subthalamic nucleus on levodopa-induced dyskinesias are likely to occur. Grip force overflow is a promising parameter to study the desensitizing effect of chronic deep-brain stimulation on levodopa-induced dyskinesias.

Authors+Show Affiliations

Department of Neurology, Christian Albrechts University, Kiel, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12210799

Citation

Wenzelburger, Roland, et al. "Dyskinesias and Grip Control in Parkinson's Disease Are Normalized By Chronic Stimulation of the Subthalamic Nucleus." Annals of Neurology, vol. 52, no. 2, 2002, pp. 240-3.
Wenzelburger R, Zhang BR, Poepping M, et al. Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus. Ann Neurol. 2002;52(2):240-3.
Wenzelburger, R., Zhang, B. R., Poepping, M., Schrader, B., Müller, D., Kopper, F., Fietzek, U., Mehdorn, H. M., Deuschl, G., & Krack, P. (2002). Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus. Annals of Neurology, 52(2), 240-3.
Wenzelburger R, et al. Dyskinesias and Grip Control in Parkinson's Disease Are Normalized By Chronic Stimulation of the Subthalamic Nucleus. Ann Neurol. 2002;52(2):240-3. PubMed PMID: 12210799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus. AU - Wenzelburger,Roland, AU - Zhang,Bao-Rong, AU - Poepping,Meike, AU - Schrader,Bettina, AU - Müller,Dieter, AU - Kopper,Florian, AU - Fietzek,Urban, AU - Mehdorn,Hubertus M, AU - Deuschl,Günther, AU - Krack,Paul, PY - 2002/9/5/pubmed PY - 2002/9/19/medline PY - 2002/9/5/entrez SP - 240 EP - 3 JF - Annals of neurology JO - Ann Neurol VL - 52 IS - 2 N2 - Deep-brain stimulation of the subthalamic nucleus appears to reduce levodopa-induced dyskinesias, but whether this effect is caused by the reduction of the total levodopa ingestion or represents a direct effect on the motor system is unknown. Precision grip force of grasping movements and levodopa-induced dyskinesias was analyzed in 10 parkinsonian patients before and after 3 months of deep-brain stimulation of the subthalamic nucleus. Peak grip force was abnormally increased before surgery in the off-drug state and, particularly, in the on-drug state (sensitization). This grip force upregulation normalized with chronic deep-brain stimulation in both conditions (desensitization). Peak-dose dyskinesias also improved, and off-dystonia was completely abolished. Mean dosage of dopaminergic drugs was reduced, but force overflow and dyskinesias were equally improved in 2 patients without a reduction. Despite the same single levodopa test dose, force excess and levodopa-induced dyskinesias were drastically reduced after 3 months of deep-brain stimulation of the subthalamic nucleus. This indicates that direct effects of deep-brain stimulation of the subthalamic nucleus on levodopa-induced dyskinesias are likely to occur. Grip force overflow is a promising parameter to study the desensitizing effect of chronic deep-brain stimulation on levodopa-induced dyskinesias. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/12210799/Dyskinesias_and_grip_control_in_Parkinson's_disease_are_normalized_by_chronic_stimulation_of_the_subthalamic_nucleus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2002&volume=52&issue=2&spage=240 DB - PRIME DP - Unbound Medicine ER -