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The role of Epstein-Barr virus-encoded small RNAs (EBERs) in oncogenesis.
Rev Med Virol 2002 Sep-Oct; 12(5):321-6RM

Abstract

Epstein-Barr virus (EBV)-encoded RNAs (EBERs) are the most abundant viral transcripts in latently EBV-infected cells. Recently, we found that EBERs play a key role in the maintenance of malignant phenotypes of Burkitt's lymphoma (BL) cells. They confer clonability in soft agarose, tumorigenicity in immunodeficient mice, resistance to apoptosis and induction of interleukin (IL)-10, which acts as an autocrine growth factor of BL cells. Furthermore, we demonstrated that EBERs confer resistance to interferon (IFN)-alpha-induced apoptosis by inhibition of double-stranded (ds) RNA-activated protein kinase (PKR), which is the key mediator of the antiviral effect of IFN-alpha. These studies provide a new notion that RNA molecules contribute to oncogenesis.

Authors+Show Affiliations

Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12211044

Citation

Nanbo, Asuka, and Kenzo Takada. "The Role of Epstein-Barr Virus-encoded Small RNAs (EBERs) in Oncogenesis." Reviews in Medical Virology, vol. 12, no. 5, 2002, pp. 321-6.
Nanbo A, Takada K. The role of Epstein-Barr virus-encoded small RNAs (EBERs) in oncogenesis. Rev Med Virol. 2002;12(5):321-6.
Nanbo, A., & Takada, K. (2002). The role of Epstein-Barr virus-encoded small RNAs (EBERs) in oncogenesis. Reviews in Medical Virology, 12(5), pp. 321-6.
Nanbo A, Takada K. The Role of Epstein-Barr Virus-encoded Small RNAs (EBERs) in Oncogenesis. Rev Med Virol. 2002;12(5):321-6. PubMed PMID: 12211044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of Epstein-Barr virus-encoded small RNAs (EBERs) in oncogenesis. AU - Nanbo,Asuka, AU - Takada,Kenzo, PY - 2002/9/5/pubmed PY - 2002/11/26/medline PY - 2002/9/5/entrez SP - 321 EP - 6 JF - Reviews in medical virology JO - Rev. Med. Virol. VL - 12 IS - 5 N2 - Epstein-Barr virus (EBV)-encoded RNAs (EBERs) are the most abundant viral transcripts in latently EBV-infected cells. Recently, we found that EBERs play a key role in the maintenance of malignant phenotypes of Burkitt's lymphoma (BL) cells. They confer clonability in soft agarose, tumorigenicity in immunodeficient mice, resistance to apoptosis and induction of interleukin (IL)-10, which acts as an autocrine growth factor of BL cells. Furthermore, we demonstrated that EBERs confer resistance to interferon (IFN)-alpha-induced apoptosis by inhibition of double-stranded (ds) RNA-activated protein kinase (PKR), which is the key mediator of the antiviral effect of IFN-alpha. These studies provide a new notion that RNA molecules contribute to oncogenesis. SN - 1052-9276 UR - https://www.unboundmedicine.com/medline/citation/12211044/The_role_of_Epstein_Barr_virus_encoded_small_RNAs__EBERs__in_oncogenesis_ L2 - https://doi.org/10.1002/rmv.363 DB - PRIME DP - Unbound Medicine ER -