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Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites.
Med Sci Monit. 2001 May; 7 Suppl 1:316-20.MS

Abstract

It is well known that water-soluble extracts of artichoke (Cynara scolymus L.) leaves exert choleresis. When studying this effect in vitro using primary cultured rat hepatocytes and cholephilic fluorescent compounds, it was noticed that the artichoke leaf extracts not only stimulated biliary secretion, but that they also reestablished it when secretion was inhibited by addition of taurolithocholate to the culture medium. Furthermore, taurolithocholate-induced bizarre bile canalicular membrane distortions detectable by electron microscopy could be prevented by artichoke leaf extracts in a dose-dependent manner when added simultaneously with the bile acid. These effects were exerted by the flavonol luteolin and, to a lesser extent, by luteolin-7-O-glucoside, while chlorogenic acid and 1.5-dicaffeoyl quinic acid were almost ineffective. Surprisingly, metabolites produced by the cultured hepatocytes were able to stimulate biliary secretion substantially as well as prevent canalicular membrane deformation. These results demonstrate that artichoke leaf extracts exert a potent anticholestatic action at least in the case of taurolithocholate-induced cholestasis. Flavonoids and their metabolites may contribute significantly to this effect.

Authors+Show Affiliations

Institut für Biochemie, Universitätsklinikum Leipzig, Germany. rgebhardt@medizin.uni-leipzig.de

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12211745

Citation

Gebhardt, R. "Anticholestatic Activity of Flavonoids From Artichoke (Cynara Scolymus L.) and of Their Metabolites." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 7 Suppl 1, 2001, pp. 316-20.
Gebhardt R. Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites. Med Sci Monit. 2001;7 Suppl 1:316-20.
Gebhardt, R. (2001). Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 7 Suppl 1, 316-20.
Gebhardt R. Anticholestatic Activity of Flavonoids From Artichoke (Cynara Scolymus L.) and of Their Metabolites. Med Sci Monit. 2001;7 Suppl 1:316-20. PubMed PMID: 12211745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites. A1 - Gebhardt,R, PY - 2002/9/6/pubmed PY - 2002/10/9/medline PY - 2002/9/6/entrez SP - 316 EP - 20 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 7 Suppl 1 N2 - It is well known that water-soluble extracts of artichoke (Cynara scolymus L.) leaves exert choleresis. When studying this effect in vitro using primary cultured rat hepatocytes and cholephilic fluorescent compounds, it was noticed that the artichoke leaf extracts not only stimulated biliary secretion, but that they also reestablished it when secretion was inhibited by addition of taurolithocholate to the culture medium. Furthermore, taurolithocholate-induced bizarre bile canalicular membrane distortions detectable by electron microscopy could be prevented by artichoke leaf extracts in a dose-dependent manner when added simultaneously with the bile acid. These effects were exerted by the flavonol luteolin and, to a lesser extent, by luteolin-7-O-glucoside, while chlorogenic acid and 1.5-dicaffeoyl quinic acid were almost ineffective. Surprisingly, metabolites produced by the cultured hepatocytes were able to stimulate biliary secretion substantially as well as prevent canalicular membrane deformation. These results demonstrate that artichoke leaf extracts exert a potent anticholestatic action at least in the case of taurolithocholate-induced cholestasis. Flavonoids and their metabolites may contribute significantly to this effect. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/12211745/Anticholestatic_activity_of_flavonoids_from_artichoke__Cynara_scolymus_L___and_of_their_metabolites_ L2 - https://www.lens.org/lens/search?q=citation_id:12211745 DB - PRIME DP - Unbound Medicine ER -