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Insulin resistance and androgens in healthy women with different body fat distributions.
Wien Klin Wochenschr. 2002 May 15; 114(8-9):321-6.WK

Abstract

OBJECTIVE

To compare androgens and sex hormone-binding globulin (SHBG) levels, and indices of insulin sensitivity (the response of plasma insulin and C-peptide in OGTT, insulin resistance and beta-cell activity estimated with the homeostasis assessment model (HOMA model) in healthy obese premenopausal women with different body fat distributions.

PATIENTS AND METHODS

Free testosterone, androstenedione, SHBG levels and responses of plasma glucose, insulin and C-peptide in OGTT were examined in 74 healthy premenopausal women (19 with lower-body obesity (WHR < 0.80), 20 with pure abdominal obesity (WHR > 0.85), 19 with predominant abdominal obesity (WHR 0.81-0.85) and 18 normal-weight women). Insulin resistance and beta-cell function were estimated with the HOMA model.

RESULTS

Both fasting and glucose-induced insulin levels were higher in women with pure abdominal obesity than in the controls (p < 0.001) and in those with lower-body obesity (P < 0.01). Insulin resistance was also higher in women with pure abdominal obesity than in the controls (p < 0.01) and those with lower-body obesity (p < 0.05). Free testosterone (p < 0.01) was higher and SHBG (p < 0.001) was lower in women with abdominal obesity than in the control group and those with lower-body obesity. Insulin significantly correlated with SHBG, and this correlation was independent of androgens, obesity and obesity type. Beta-cell function positively correlated with free testosterone, whereas insulin resistance negatively correlated with SHBG, and was independent of obesity and obesity type.

CONCLUSIONS

In healthy premenopausal women, increased BMI and more pronounced abdominal fat accumulation was associated with increased androgenic activity (higher free testosterone and lower SHBG levels) and with insulin resistance estimated using the HOMA model, as well as with increasing basal and glucose-induced insulin levels. SHBG levels correlated with insulin and insulin resistance independently of the degree of obesity, obesity type and androgens, whereas beta-cell function correlated only with free testosterone.

Authors+Show Affiliations

Ivandić A
Department of Internal Medicine, Osijek University Hospital, Osijek, Croatia. ivandic.ante@kbo.hr
Prpić-Krizevac I
No affiliation info available
Bozić D
No affiliation info available
Barbir A
No affiliation info available
Peljhan V
No affiliation info available
Balog Z
No affiliation info available
Glasnović M
No affiliation info available

MeSH

AdultAndrogensBody CompositionBody ConstitutionBody Mass IndexC-PeptideFemaleGlucose Tolerance TestHumansInsulin ResistanceIslets of LangerhansPremenopauseReference ValuesSex Hormone-Binding Globulin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12212367

Citation

Ivandić, Ante, et al. "Insulin Resistance and Androgens in Healthy Women With Different Body Fat Distributions." Wiener Klinische Wochenschrift, vol. 114, no. 8-9, 2002, pp. 321-6.
Ivandić A, Prpić-Krizevac I, Bozić D, et al. Insulin resistance and androgens in healthy women with different body fat distributions. Wien Klin Wochenschr. 2002;114(8-9):321-6.
Ivandić, A., Prpić-Krizevac, I., Bozić, D., Barbir, A., Peljhan, V., Balog, Z., & Glasnović, M. (2002). Insulin resistance and androgens in healthy women with different body fat distributions. Wiener Klinische Wochenschrift, 114(8-9), 321-6.
Ivandić A, et al. Insulin Resistance and Androgens in Healthy Women With Different Body Fat Distributions. Wien Klin Wochenschr. 2002 May 15;114(8-9):321-6. PubMed PMID: 12212367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance and androgens in healthy women with different body fat distributions. AU - Ivandić,Ante, AU - Prpić-Krizevac,Ivana, AU - Bozić,Dubravko, AU - Barbir,Ante, AU - Peljhan,Vladimir, AU - Balog,Zlatko, AU - Glasnović,Marija, PY - 2002/9/6/pubmed PY - 2002/10/31/medline PY - 2002/9/6/entrez SP - 321 EP - 6 JF - Wiener klinische Wochenschrift JO - Wien Klin Wochenschr VL - 114 IS - 8-9 N2 - OBJECTIVE: To compare androgens and sex hormone-binding globulin (SHBG) levels, and indices of insulin sensitivity (the response of plasma insulin and C-peptide in OGTT, insulin resistance and beta-cell activity estimated with the homeostasis assessment model (HOMA model) in healthy obese premenopausal women with different body fat distributions. PATIENTS AND METHODS: Free testosterone, androstenedione, SHBG levels and responses of plasma glucose, insulin and C-peptide in OGTT were examined in 74 healthy premenopausal women (19 with lower-body obesity (WHR < 0.80), 20 with pure abdominal obesity (WHR > 0.85), 19 with predominant abdominal obesity (WHR 0.81-0.85) and 18 normal-weight women). Insulin resistance and beta-cell function were estimated with the HOMA model. RESULTS: Both fasting and glucose-induced insulin levels were higher in women with pure abdominal obesity than in the controls (p < 0.001) and in those with lower-body obesity (P < 0.01). Insulin resistance was also higher in women with pure abdominal obesity than in the controls (p < 0.01) and those with lower-body obesity (p < 0.05). Free testosterone (p < 0.01) was higher and SHBG (p < 0.001) was lower in women with abdominal obesity than in the control group and those with lower-body obesity. Insulin significantly correlated with SHBG, and this correlation was independent of androgens, obesity and obesity type. Beta-cell function positively correlated with free testosterone, whereas insulin resistance negatively correlated with SHBG, and was independent of obesity and obesity type. CONCLUSIONS: In healthy premenopausal women, increased BMI and more pronounced abdominal fat accumulation was associated with increased androgenic activity (higher free testosterone and lower SHBG levels) and with insulin resistance estimated using the HOMA model, as well as with increasing basal and glucose-induced insulin levels. SHBG levels correlated with insulin and insulin resistance independently of the degree of obesity, obesity type and androgens, whereas beta-cell function correlated only with free testosterone. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/12212367/Insulin_resistance_and_androgens_in_healthy_women_with_different_body_fat_distributions_ DB - PRIME DP - Unbound Medicine ER -