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Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease.
Psychophysiology. 2002 Mar; 39(2):175-81.P

Abstract

Accurate and early diagnosis of Alzheimer's Disease (AD) with reliable and noninvasive methods is of great importance for clinical practice as effective and specific antidementive therapies become available. The aim of the study was to evaluate the clinical relevance of event-related P300 in the early diagnosis of AD. Thirty patients with AD, 26 patients with mild cognitive impairment (MCI) from our Memory Clinic and 26 age-matched healthy controls (HC) were studied with event-related P300 potentials. Amplitudes of temporo-basal dipoles (TB-P300) were significantly diminished in AD compared to HC and MCI. Furthermore, latencies of temporo-superior dipoles (TS-P300) were significantly prolonged in AD compared with HC. Sensitivity was 90.0% for the differentiation of patients with AD from HC (specificity 79.1%) using reduced TB-P300 amplitudes and prolonged TS-P300 latencies. Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD.

Authors+Show Affiliations

Department of Psychiatry, Ludwig-Maximilians University Munich, Germany. tfrodlba@psy.med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12212666

Citation

Frodl, Thomas, et al. "Value of Event-related P300 Subcomponents in the Clinical Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease." Psychophysiology, vol. 39, no. 2, 2002, pp. 175-81.
Frodl T, Hampel H, Juckel G, et al. Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease. Psychophysiology. 2002;39(2):175-81.
Frodl, T., Hampel, H., Juckel, G., Bürger, K., Padberg, F., Engel, R. R., Möller, H. J., & Hegerl, U. (2002). Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease. Psychophysiology, 39(2), 175-81.
Frodl T, et al. Value of Event-related P300 Subcomponents in the Clinical Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease. Psychophysiology. 2002;39(2):175-81. PubMed PMID: 12212666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease. AU - Frodl,Thomas, AU - Hampel,Harald, AU - Juckel,Georg, AU - Bürger,Katharina, AU - Padberg,Frank, AU - Engel,Rolf R, AU - Möller,Hans-Jürgen, AU - Hegerl,Ulrich, PY - 2002/9/6/pubmed PY - 2002/10/3/medline PY - 2002/9/6/entrez SP - 175 EP - 81 JF - Psychophysiology JO - Psychophysiology VL - 39 IS - 2 N2 - Accurate and early diagnosis of Alzheimer's Disease (AD) with reliable and noninvasive methods is of great importance for clinical practice as effective and specific antidementive therapies become available. The aim of the study was to evaluate the clinical relevance of event-related P300 in the early diagnosis of AD. Thirty patients with AD, 26 patients with mild cognitive impairment (MCI) from our Memory Clinic and 26 age-matched healthy controls (HC) were studied with event-related P300 potentials. Amplitudes of temporo-basal dipoles (TB-P300) were significantly diminished in AD compared to HC and MCI. Furthermore, latencies of temporo-superior dipoles (TS-P300) were significantly prolonged in AD compared with HC. Sensitivity was 90.0% for the differentiation of patients with AD from HC (specificity 79.1%) using reduced TB-P300 amplitudes and prolonged TS-P300 latencies. Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD. SN - 0048-5772 UR - https://www.unboundmedicine.com/medline/citation/12212666/Value_of_event_related_P300_subcomponents_in_the_clinical_diagnosis_of_mild_cognitive_impairment_and_Alzheimer's_Disease_ L2 - https://doi.org/10.1017/S0048577202010260 DB - PRIME DP - Unbound Medicine ER -