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Lack of effect of long-term use of angiotensin-converting enzyme inhibitors by hemodialysis patients on thirst and fluid weight gain.
Ren Fail. 2002 Jul; 24(4):461-6.RF

Abstract

Volume overload is a chronic, troublesome problem in many patients on hemodialysis. These patients suffer from hyperdipsia with inability to excrete water. Angiotensin-converting enzyme inhibitor (ACEI) has been shown to decrease thirst and interdialytic weight gain in 2-4 weeks of usage. We investigated the effect of long-term use of ACEI, as levels of angiotensin II tends to go back to normal level after 6 months of use. We compared hemodialysis patients on ACEI for more than 6 months to patients not on ACEI. Seven patients were taking ACEI compared to 51 controls in the other group. Almost one third of patients in each group had an interdialytic weight gain > 5% of dry weight. No significant difference was found between the two groups with regard to interdialytic weight gain, thirst and mouth dryness scores, and interdialytic mean blood pressure change. There was no demonstrable effect of angiotensin receptor blocking drugs on weight gain or thirst. We conclude that long-term ACEI may not continue to suppress inappropriate thirst and fluid intake after 6 months in hemodialysis patients.

Authors+Show Affiliations

Department of Medicine, Nassau University Medical Center, East Meadow, NY 11554, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12212825

Citation

Hamad, Abdullah, et al. "Lack of Effect of Long-term Use of Angiotensin-converting Enzyme Inhibitors By Hemodialysis Patients On Thirst and Fluid Weight Gain." Renal Failure, vol. 24, no. 4, 2002, pp. 461-6.
Hamad A, Khosrovaneh A, Gupta S, et al. Lack of effect of long-term use of angiotensin-converting enzyme inhibitors by hemodialysis patients on thirst and fluid weight gain. Ren Fail. 2002;24(4):461-6.
Hamad, A., Khosrovaneh, A., Gupta, S., Fazal, S., Manis, T., & Feinfeld, D. A. (2002). Lack of effect of long-term use of angiotensin-converting enzyme inhibitors by hemodialysis patients on thirst and fluid weight gain. Renal Failure, 24(4), 461-6.
Hamad A, et al. Lack of Effect of Long-term Use of Angiotensin-converting Enzyme Inhibitors By Hemodialysis Patients On Thirst and Fluid Weight Gain. Ren Fail. 2002;24(4):461-6. PubMed PMID: 12212825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of effect of long-term use of angiotensin-converting enzyme inhibitors by hemodialysis patients on thirst and fluid weight gain. AU - Hamad,Abdullah, AU - Khosrovaneh,Amir, AU - Gupta,Sumati, AU - Fazal,Samina, AU - Manis,Thomas, AU - Feinfeld,Donald A, PY - 2002/9/6/pubmed PY - 2003/3/12/medline PY - 2002/9/6/entrez SP - 461 EP - 6 JF - Renal failure JO - Ren Fail VL - 24 IS - 4 N2 - Volume overload is a chronic, troublesome problem in many patients on hemodialysis. These patients suffer from hyperdipsia with inability to excrete water. Angiotensin-converting enzyme inhibitor (ACEI) has been shown to decrease thirst and interdialytic weight gain in 2-4 weeks of usage. We investigated the effect of long-term use of ACEI, as levels of angiotensin II tends to go back to normal level after 6 months of use. We compared hemodialysis patients on ACEI for more than 6 months to patients not on ACEI. Seven patients were taking ACEI compared to 51 controls in the other group. Almost one third of patients in each group had an interdialytic weight gain > 5% of dry weight. No significant difference was found between the two groups with regard to interdialytic weight gain, thirst and mouth dryness scores, and interdialytic mean blood pressure change. There was no demonstrable effect of angiotensin receptor blocking drugs on weight gain or thirst. We conclude that long-term ACEI may not continue to suppress inappropriate thirst and fluid intake after 6 months in hemodialysis patients. SN - 0886-022X UR - https://www.unboundmedicine.com/medline/citation/12212825/Lack_of_effect_of_long_term_use_of_angiotensin_converting_enzyme_inhibitors_by_hemodialysis_patients_on_thirst_and_fluid_weight_gain_ L2 - https://www.tandfonline.com/doi/full/10.1081/jdi-120006772 DB - PRIME DP - Unbound Medicine ER -