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Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: relevance to hypoxia/reoxygenation injury.
Cardiovasc Toxicol 2001; 1(3):205-13CT

Abstract

The cardioprotective properties of new pharmaceuticals such as carvedilol might be explained by enhanced mitochondrial protection. The aim of this work was to determine the role of carvedilol in the protection of heart mitochondria from oxidative damage induced by hypoxanthine/xanthine oxidase, a known source of oxidative stress in the vascular system. Carvedilol reduced oxidative-stress-induced mitochondrial injury, as seen by the delay in the loss of the mitochondrial transmembranar potential (Delta Psi), the decrease in mitochondrial swelling, and the increase in mitochondrial calcium uptake. Carvedilol improved the mitochondrial respiratory activity in state III and offered an overall protection in the respiratory control and in the P/O ratios in mitochondria under oxidative stress. The data indicated that carvedilol was able to partly protect heart mitochondria from oxidative stress-induced damage. Our results suggest that mitochondria can be important targets for some cardioprotective pharmaceuticals.

Authors+Show Affiliations

Centro de Neurociências e Biologia Celular de Coimbra, Departamento Zoologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, P-3004-517 Coimbra, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12213973

Citation

Oliveira, P J., et al. "Carvedilol Reduces Mitochondrial Damage Induced By Hypoxanthine/xanthine Oxidase: Relevance to Hypoxia/reoxygenation Injury." Cardiovascular Toxicology, vol. 1, no. 3, 2001, pp. 205-13.
Oliveira PJ, Rolo AP, Palmeira CM, et al. Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: relevance to hypoxia/reoxygenation injury. Cardiovasc Toxicol. 2001;1(3):205-13.
Oliveira, P. J., Rolo, A. P., Palmeira, C. M., & Moreno, A. J. (2001). Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: relevance to hypoxia/reoxygenation injury. Cardiovascular Toxicology, 1(3), pp. 205-13.
Oliveira PJ, et al. Carvedilol Reduces Mitochondrial Damage Induced By Hypoxanthine/xanthine Oxidase: Relevance to Hypoxia/reoxygenation Injury. Cardiovasc Toxicol. 2001;1(3):205-13. PubMed PMID: 12213973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: relevance to hypoxia/reoxygenation injury. AU - Oliveira,P J, AU - Rolo,A P, AU - Palmeira,C M, AU - Moreno,A J, PY - 2002/9/6/pubmed PY - 2002/10/9/medline PY - 2002/9/6/entrez SP - 205 EP - 13 JF - Cardiovascular toxicology JO - Cardiovasc. Toxicol. VL - 1 IS - 3 N2 - The cardioprotective properties of new pharmaceuticals such as carvedilol might be explained by enhanced mitochondrial protection. The aim of this work was to determine the role of carvedilol in the protection of heart mitochondria from oxidative damage induced by hypoxanthine/xanthine oxidase, a known source of oxidative stress in the vascular system. Carvedilol reduced oxidative-stress-induced mitochondrial injury, as seen by the delay in the loss of the mitochondrial transmembranar potential (Delta Psi), the decrease in mitochondrial swelling, and the increase in mitochondrial calcium uptake. Carvedilol improved the mitochondrial respiratory activity in state III and offered an overall protection in the respiratory control and in the P/O ratios in mitochondria under oxidative stress. The data indicated that carvedilol was able to partly protect heart mitochondria from oxidative stress-induced damage. Our results suggest that mitochondria can be important targets for some cardioprotective pharmaceuticals. SN - 1530-7905 UR - https://www.unboundmedicine.com/medline/citation/12213973/Carvedilol_reduces_mitochondrial_damage_induced_by_hypoxanthine/xanthine_oxidase:_relevance_to_hypoxia/reoxygenation_injury_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12213973.ui DB - PRIME DP - Unbound Medicine ER -