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Age specific and attributable risks of familial prostate carcinoma from the family-cancer database.
Cancer. 2002 Sep 15; 95(6):1346-53.C

Abstract

BACKGROUND

Familial risks by proband status and age are useful for clinical counseling, and they can be used to calculate population-attributable fractions (PAFs), which show the proportion of disease that could be prevented if the cause could be removed.

METHODS

The authors used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 182,104 fathers and 3710 sons with medically verified prostate carcinoma to calculate age specific familial standardized incidence ratios (SIRs) with 95% confidence intervals (95%CI) and familial PAFs for prostate carcinoma in sons ages 0-66 years.

RESULTS

The incidence of prostate carcinoma was doubled between the years 1961 and 1998. The familial SIRs for prostate carcinoma were 2.38 (95%CI, 2.18-2.59) for men with prostate carcinoma in the father only, 3.75 (95%CI, 2.73-4.95) for men with prostate carcinoma in a brother only, and 9.44 (95%CI, 5.76-14.03) for men with prostate carcinoma in both a father and a brother. The corresponding familial PAFs were 8.86%, 1.78%, and 0.99%, respectively, yielding a total PAF of 11.63%. Age specific risks were shown for the same proband histories. The SIR was 8.05 for prostate carcinoma before age 55 if a brother had been diagnosed before that age. If, in addition, a father was diagnosed at any age, then the SIR was 33.09.

CONCLUSIONS

The authors recommend that having a brother who is diagnosed with prostate carcinoma before age 55 years or having a brother and father who are diagnosed at any age are indications to screen for prostate carcinoma. The familial PAF of prostate carcinoma among a population of sons ages 0-66 years was 11.63%.

Authors+Show Affiliations

Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden. kari.hemminki@cnt.ki.seNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12216104

Citation

Hemminki, Kari, and Kamila Czene. "Age Specific and Attributable Risks of Familial Prostate Carcinoma From the Family-cancer Database." Cancer, vol. 95, no. 6, 2002, pp. 1346-53.
Hemminki K, Czene K. Age specific and attributable risks of familial prostate carcinoma from the family-cancer database. Cancer. 2002;95(6):1346-53.
Hemminki, K., & Czene, K. (2002). Age specific and attributable risks of familial prostate carcinoma from the family-cancer database. Cancer, 95(6), 1346-53.
Hemminki K, Czene K. Age Specific and Attributable Risks of Familial Prostate Carcinoma From the Family-cancer Database. Cancer. 2002 Sep 15;95(6):1346-53. PubMed PMID: 12216104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age specific and attributable risks of familial prostate carcinoma from the family-cancer database. AU - Hemminki,Kari, AU - Czene,Kamila, PY - 2002/9/7/pubmed PY - 2002/9/28/medline PY - 2002/9/7/entrez SP - 1346 EP - 53 JF - Cancer JO - Cancer VL - 95 IS - 6 N2 - BACKGROUND: Familial risks by proband status and age are useful for clinical counseling, and they can be used to calculate population-attributable fractions (PAFs), which show the proportion of disease that could be prevented if the cause could be removed. METHODS: The authors used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 182,104 fathers and 3710 sons with medically verified prostate carcinoma to calculate age specific familial standardized incidence ratios (SIRs) with 95% confidence intervals (95%CI) and familial PAFs for prostate carcinoma in sons ages 0-66 years. RESULTS: The incidence of prostate carcinoma was doubled between the years 1961 and 1998. The familial SIRs for prostate carcinoma were 2.38 (95%CI, 2.18-2.59) for men with prostate carcinoma in the father only, 3.75 (95%CI, 2.73-4.95) for men with prostate carcinoma in a brother only, and 9.44 (95%CI, 5.76-14.03) for men with prostate carcinoma in both a father and a brother. The corresponding familial PAFs were 8.86%, 1.78%, and 0.99%, respectively, yielding a total PAF of 11.63%. Age specific risks were shown for the same proband histories. The SIR was 8.05 for prostate carcinoma before age 55 if a brother had been diagnosed before that age. If, in addition, a father was diagnosed at any age, then the SIR was 33.09. CONCLUSIONS: The authors recommend that having a brother who is diagnosed with prostate carcinoma before age 55 years or having a brother and father who are diagnosed at any age are indications to screen for prostate carcinoma. The familial PAF of prostate carcinoma among a population of sons ages 0-66 years was 11.63%. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12216104/Age_specific_and_attributable_risks_of_familial_prostate_carcinoma_from_the_family_cancer_database_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0008-543X&date=2002&volume=95&issue=6&spage=1346 DB - PRIME DP - Unbound Medicine ER -