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Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain.
Am J Orthop (Belle Mead NJ) 2002; 31(8):445-51AJ

Abstract

Ankle sprain is a common acute soft-tissue injury that often results in pain, inflammation, and ecchymosis. In this multicenter, double-blind, randomized parallel-group study, 445 adult patients received celecoxib 400 mg/day, ibuprofen 2,400 mg/day, or placebo for 10 days. Patients had experienced grade 1 or 2 ankle sprains within 48 hours and had moderate to severe ankle pain. Patient's Global Assessment of Ankle Injury responses, given on days 4 and 8, showed that the celecoxib group improved significantly more than the placebo group did, with 67% of the celecoxib group versus 55% of the placebo group improving at day 4 (P < .05). Patient's Assessment of Ankle Pain Visual Analog Scale on Weight Bearing responses, also given on days 4 and 8, showed that celecoxib was as efficacious in the treatment of ankle sprain as the maximum therapeutic dosage of ibuprofen and that, compared with placebo, it reduced pain significantly more (P < .05). The celecoxib group recovered and returned to function earlier (after 5 days) than did either the placebo group (8 days) or the ibuprofen group (6 days); the celecoxib-placebo difference was significant. Celecoxib, a cyclo-oxygenase-2-specific inhibitor with platelet-function-sparing properties, may be useful as a multimodal adjuvant in the treatment of ankle sprain.

Authors+Show Affiliations

Southern Orthopaedic Sports Medicine, Providence Hospital Columbia, South Carolina, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

12216965

Citation

Ekman, Evan F., et al. "Efficacy of Celecoxib Versus Ibuprofen in the Treatment of Acute Pain: a Multicenter, Double-blind, Randomized Controlled Trial in Acute Ankle Sprain." American Journal of Orthopedics (Belle Mead, N.J.), vol. 31, no. 8, 2002, pp. 445-51.
Ekman EF, Fiechtner JJ, Levy S, et al. Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain. Am J Orthop. 2002;31(8):445-51.
Ekman, E. F., Fiechtner, J. J., Levy, S., & Fort, J. G. (2002). Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain. American Journal of Orthopedics (Belle Mead, N.J.), 31(8), pp. 445-51.
Ekman EF, et al. Efficacy of Celecoxib Versus Ibuprofen in the Treatment of Acute Pain: a Multicenter, Double-blind, Randomized Controlled Trial in Acute Ankle Sprain. Am J Orthop. 2002;31(8):445-51. PubMed PMID: 12216965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain. AU - Ekman,Evan F, AU - Fiechtner,Justus J, AU - Levy,Stephane, AU - Fort,John G, PY - 2002/9/10/pubmed PY - 2003/1/23/medline PY - 2002/9/10/entrez SP - 445 EP - 51 JF - American journal of orthopedics (Belle Mead, N.J.) JO - Am J. Orthop. VL - 31 IS - 8 N2 - Ankle sprain is a common acute soft-tissue injury that often results in pain, inflammation, and ecchymosis. In this multicenter, double-blind, randomized parallel-group study, 445 adult patients received celecoxib 400 mg/day, ibuprofen 2,400 mg/day, or placebo for 10 days. Patients had experienced grade 1 or 2 ankle sprains within 48 hours and had moderate to severe ankle pain. Patient's Global Assessment of Ankle Injury responses, given on days 4 and 8, showed that the celecoxib group improved significantly more than the placebo group did, with 67% of the celecoxib group versus 55% of the placebo group improving at day 4 (P < .05). Patient's Assessment of Ankle Pain Visual Analog Scale on Weight Bearing responses, also given on days 4 and 8, showed that celecoxib was as efficacious in the treatment of ankle sprain as the maximum therapeutic dosage of ibuprofen and that, compared with placebo, it reduced pain significantly more (P < .05). The celecoxib group recovered and returned to function earlier (after 5 days) than did either the placebo group (8 days) or the ibuprofen group (6 days); the celecoxib-placebo difference was significant. Celecoxib, a cyclo-oxygenase-2-specific inhibitor with platelet-function-sparing properties, may be useful as a multimodal adjuvant in the treatment of ankle sprain. SN - 1078-4519 UR - https://www.unboundmedicine.com/medline/citation/12216965/Efficacy_of_celecoxib_versus_ibuprofen_in_the_treatment_of_acute_pain:_a_multicenter_double_blind_randomized_controlled_trial_in_acute_ankle_sprain_ L2 - https://medlineplus.gov/ankleinjuriesanddisorders.html DB - PRIME DP - Unbound Medicine ER -