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Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity.

Abstract

OBJECTIVE

To evaluate the association between celiac disease and specific anxiety and depressive disorders and to identify potential common pathogenetic links, with particular regard to thyroid function and autoimmunity.

METHODS

Cases included 36 adult celiac patients, 25 females and 11 males, aged 18-64 years. Controls comprised 144 healthy subjects matched by sex and age with no clinical evidence or family history of celiac disease. Diagnosis of celiac disease was made on the basis of clinical history and serological criteria. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview, according to DSM-IV criteria. Thyroid was evaluated by palpation, echography and measurement of serum-free thyroid hormones (FT4, FT3), thyroid-stimulating hormone (TSH) and antithyroid autoantibodies (anti-TPO).

RESULTS

Compared to controls, a significantly higher number of celiac patients met criteria for lifetime [15 (41.7%) versus 30 (29.8%), P < .01] and 6-month [7 (19.4%) versus 9 (6.2%), OR = 3.2, chi(2) = 5.2, P < .05] major depressive disorder (MDD) and lifetime [5 (13.9%) versus 3 (2.1%), P < .001] and 6-month [3 (8.1%) versus 2 (1.4%), P < .05] panic disorder (PD). Anti-TPO prevalence was significantly higher in celiac patients than in the control group (11/36 = 30.5% versus 14/144 = 9.7%, P < .001). A higher frequency of PD and MDD was found in celiac patients with positive anti-TPO when compared to negative anti-TPO patients (4/11 = 36.4% PD in TPO+ versus 1/25 = 4% PD in TPO-, P < .01; 9/11 = 81.8% MD in TPO+ versus 6/25 = 9.5% MD in TPO-, P < .01).

CONCLUSION

Patients affected by celiac disease tend to show a high prevalence of PD and MDD and association with subclinical thyroid disease appears to represent a significant risk factor for these psychiatric disorders.

Links

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  • Authors+Show Affiliations

    ,

    Division of Psychiatry, Department of Public Health, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy. mgcarta@tiscali.it

    , , , ,

    Source

    Journal of psychosomatic research 53:3 2002 Sep pg 789-93

    MeSH

    Adolescent
    Adult
    Celiac Disease
    Depressive Disorder
    Female
    Humans
    Male
    Middle Aged
    Panic Disorder
    Prevalence
    Risk Factors
    Thyroiditis, Autoimmune
    Thyrotropin

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12217453

    Citation

    Carta, Mauro Giovanni, et al. "Association Between Panic Disorder, Major Depressive Disorder and Celiac Disease: a Possible Role of Thyroid Autoimmunity." Journal of Psychosomatic Research, vol. 53, no. 3, 2002, pp. 789-93.
    Carta MG, Hardoy MC, Boi MF, et al. Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity. J Psychosom Res. 2002;53(3):789-93.
    Carta, M. G., Hardoy, M. C., Boi, M. F., Mariotti, S., Carpiniello, B., & Usai, P. (2002). Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity. Journal of Psychosomatic Research, 53(3), pp. 789-93.
    Carta MG, et al. Association Between Panic Disorder, Major Depressive Disorder and Celiac Disease: a Possible Role of Thyroid Autoimmunity. J Psychosom Res. 2002;53(3):789-93. PubMed PMID: 12217453.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity. AU - Carta,Mauro Giovanni, AU - Hardoy,Maria Carolina, AU - Boi,Maria Francesca, AU - Mariotti,Stefano, AU - Carpiniello,Bernardo, AU - Usai,Paolo, PY - 2002/9/10/pubmed PY - 2002/11/26/medline PY - 2002/9/10/entrez SP - 789 EP - 93 JF - Journal of psychosomatic research JO - J Psychosom Res VL - 53 IS - 3 N2 - OBJECTIVE: To evaluate the association between celiac disease and specific anxiety and depressive disorders and to identify potential common pathogenetic links, with particular regard to thyroid function and autoimmunity. METHODS: Cases included 36 adult celiac patients, 25 females and 11 males, aged 18-64 years. Controls comprised 144 healthy subjects matched by sex and age with no clinical evidence or family history of celiac disease. Diagnosis of celiac disease was made on the basis of clinical history and serological criteria. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview, according to DSM-IV criteria. Thyroid was evaluated by palpation, echography and measurement of serum-free thyroid hormones (FT4, FT3), thyroid-stimulating hormone (TSH) and antithyroid autoantibodies (anti-TPO). RESULTS: Compared to controls, a significantly higher number of celiac patients met criteria for lifetime [15 (41.7%) versus 30 (29.8%), P < .01] and 6-month [7 (19.4%) versus 9 (6.2%), OR = 3.2, chi(2) = 5.2, P < .05] major depressive disorder (MDD) and lifetime [5 (13.9%) versus 3 (2.1%), P < .001] and 6-month [3 (8.1%) versus 2 (1.4%), P < .05] panic disorder (PD). Anti-TPO prevalence was significantly higher in celiac patients than in the control group (11/36 = 30.5% versus 14/144 = 9.7%, P < .001). A higher frequency of PD and MDD was found in celiac patients with positive anti-TPO when compared to negative anti-TPO patients (4/11 = 36.4% PD in TPO+ versus 1/25 = 4% PD in TPO-, P < .01; 9/11 = 81.8% MD in TPO+ versus 6/25 = 9.5% MD in TPO-, P < .01). CONCLUSION: Patients affected by celiac disease tend to show a high prevalence of PD and MDD and association with subclinical thyroid disease appears to represent a significant risk factor for these psychiatric disorders. SN - 0022-3999 UR - https://www.unboundmedicine.com/medline/citation/12217453/Association_between_panic_disorder_major_depressive_disorder_and_celiac_disease:_a_possible_role_of_thyroid_autoimmunity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022399902003288 DB - PRIME DP - Unbound Medicine ER -