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[Cutaneous T-cell lymphoma, cutaneous hyperpigmentation and paraneoplastic pemphigus].
Ann Dermatol Venereol. 2002 Jun-Jul; 129(6-7):896-900.AD

Abstract

BACKGROUND

Paraneoplastic pemphigus is an autoimmune mucocutaneous disease usually associated with neoplasia as lymphoid proliferations. We report the original case of a patient who had developed a mycosis fongoide preceded by a paraneoplastic pemphigus. To our knowledge, this association has never been reported before. Cutaneous manifestations of mycosis fongoide as pigmentary change are known. This mycosis fongoide was particular in its progressive cutaneous hyperpigmentation.

CASE REPORT

A 70-year-old male patient developed a mycosis fongoide with CD30 positive cells in the dermis several months after the diagnosis of a paraneoplastic pemphigus. Simultaneously, a cutaneous hyperpigmentation was predominantly noticed on photo-exposed areas, which improved after chemotherapy.

DISCUSSION

Paraneoplastic pemphigus may precede the cancer, as is shown by our present case. This paraneoplastic pemphigus is singular because of the lack of oral erosions, patient's prolonged survival and its association with a mycosis fongoide. The diagnosis of mycosis fongoide with CD30 + cells was finally established together with its relationship to the cutaneous hyperpigmentation. Indeed, a few cases of pigmentary changes in mycosis fongoide have already been reported. The pathogenesis is still unknown, but the role of mast cell and stem cell factor in hyperpigmented mycosis fongoide has been proposed.

Authors+Show Affiliations

Service de Dermatologie, Hôpital Nord, Marseille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

12218920

Citation

De Saint Paul, G, et al. "[Cutaneous T-cell Lymphoma, Cutaneous Hyperpigmentation and Paraneoplastic Pemphigus]." Annales De Dermatologie Et De Venereologie, vol. 129, no. 6-7, 2002, pp. 896-900.
De Saint Paul G, Albès B, Bayle P, et al. [Cutaneous T-cell lymphoma, cutaneous hyperpigmentation and paraneoplastic pemphigus]. Ann Dermatol Venereol. 2002;129(6-7):896-900.
De Saint Paul, G., Albès, B., Bayle, P., Lamant, L., & Bazex, J. (2002). [Cutaneous T-cell lymphoma, cutaneous hyperpigmentation and paraneoplastic pemphigus]. Annales De Dermatologie Et De Venereologie, 129(6-7), 896-900.
De Saint Paul G, et al. [Cutaneous T-cell Lymphoma, Cutaneous Hyperpigmentation and Paraneoplastic Pemphigus]. Ann Dermatol Venereol. 2002 Jun-Jul;129(6-7):896-900. PubMed PMID: 12218920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cutaneous T-cell lymphoma, cutaneous hyperpigmentation and paraneoplastic pemphigus]. AU - De Saint Paul,G, AU - Albès,B, AU - Bayle,P, AU - Lamant,L, AU - Bazex,J, PY - 2002/9/10/pubmed PY - 2002/10/31/medline PY - 2002/9/10/entrez SP - 896 EP - 900 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 129 IS - 6-7 N2 - BACKGROUND: Paraneoplastic pemphigus is an autoimmune mucocutaneous disease usually associated with neoplasia as lymphoid proliferations. We report the original case of a patient who had developed a mycosis fongoide preceded by a paraneoplastic pemphigus. To our knowledge, this association has never been reported before. Cutaneous manifestations of mycosis fongoide as pigmentary change are known. This mycosis fongoide was particular in its progressive cutaneous hyperpigmentation. CASE REPORT: A 70-year-old male patient developed a mycosis fongoide with CD30 positive cells in the dermis several months after the diagnosis of a paraneoplastic pemphigus. Simultaneously, a cutaneous hyperpigmentation was predominantly noticed on photo-exposed areas, which improved after chemotherapy. DISCUSSION: Paraneoplastic pemphigus may precede the cancer, as is shown by our present case. This paraneoplastic pemphigus is singular because of the lack of oral erosions, patient's prolonged survival and its association with a mycosis fongoide. The diagnosis of mycosis fongoide with CD30 + cells was finally established together with its relationship to the cutaneous hyperpigmentation. Indeed, a few cases of pigmentary changes in mycosis fongoide have already been reported. The pathogenesis is still unknown, but the role of mast cell and stem cell factor in hyperpigmented mycosis fongoide has been proposed. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/12218920/[Cutaneous_T_cell_lymphoma_cutaneous_hyperpigmentation_and_paraneoplastic_pemphigus]_ DB - PRIME DP - Unbound Medicine ER -