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Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones.
Planta Med. 2002 Aug; 68(8):750-1.PM

Abstract

The anti-trypanosomal activity of six sesquiterpene lactones (helenalin, mexicanin I, 11alpha,13-dihydrohelenalin acetate, chamissonolide, ivalin and isoalantolactone) against the African Trypanosoma brucei rhodesiense and American T. cruzi was investigated. All tested compounds were found active towards both parasites, the former being generally more sensitive. Helenalin was the most active compound in the series with IC50 values of 0.051 and 0.695 microM against T. brucei rhodesiense and T. cruzi, respectively. The low IC50 value for T. b. rhodesiense indicates that helenalin type compounds may be interesting candidates for further evaluation.

Authors+Show Affiliations

Institut für Pharmazeutische Biologie der Heinrich-Heine-Universität, Düsseldorf, Germany. schmidtt@uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12221603

Citation

Schmidt, Thomas J., et al. "Anti-trypanosomal Activity of Helenalin and some Structurally Related Sesquiterpene Lactones." Planta Medica, vol. 68, no. 8, 2002, pp. 750-1.
Schmidt TJ, Brun R, Willuhn G, et al. Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones. Planta Med. 2002;68(8):750-1.
Schmidt, T. J., Brun, R., Willuhn, G., & Khalid, S. A. (2002). Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones. Planta Medica, 68(8), 750-1.
Schmidt TJ, et al. Anti-trypanosomal Activity of Helenalin and some Structurally Related Sesquiterpene Lactones. Planta Med. 2002;68(8):750-1. PubMed PMID: 12221603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones. AU - Schmidt,Thomas J, AU - Brun,Reto, AU - Willuhn,Günter, AU - Khalid,Sami A, PY - 2002/9/11/pubmed PY - 2002/11/26/medline PY - 2002/9/11/entrez SP - 750 EP - 1 JF - Planta medica JO - Planta Med VL - 68 IS - 8 N2 - The anti-trypanosomal activity of six sesquiterpene lactones (helenalin, mexicanin I, 11alpha,13-dihydrohelenalin acetate, chamissonolide, ivalin and isoalantolactone) against the African Trypanosoma brucei rhodesiense and American T. cruzi was investigated. All tested compounds were found active towards both parasites, the former being generally more sensitive. Helenalin was the most active compound in the series with IC50 values of 0.051 and 0.695 microM against T. brucei rhodesiense and T. cruzi, respectively. The low IC50 value for T. b. rhodesiense indicates that helenalin type compounds may be interesting candidates for further evaluation. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12221603/Anti_trypanosomal_activity_of_helenalin_and_some_structurally_related_sesquiterpene_lactones_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-33799 DB - PRIME DP - Unbound Medicine ER -