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A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT.
Am J Hematol. 2002 Sep; 71(1):37-40.AJ

Abstract

A 26-year-old male with acute lymphoblastic leukemia (ALL) in its second complete remission received an unrelated bone marrow transplantation (UBMT) following cyclophosphamide plus total body irradiation conditioning. The patient relapsed 7 months after the BMT. He received a second UBMT from a different donor 15 months after the initial UBMT. Conditioning for the second UBMT consisted of busulphan, melphalan, and anti-thymocyte globulin. The regimen was well tolerated, and engraftment was achieved. Both acute and chronic graft-versus-host diseases occurred but were successfully controlled with immunosuppressive drugs. He is alive and disease-free 29 months after the second UBMT. This is the first report of a successful second UBMT for ALL that had relapsed after the first UBMT and for which a different donor was used.

Authors+Show Affiliations

Second Department of Internal Medicine, Chiba University Graduate School of Medicine, Chiba City, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12221672

Citation

Uehara, Taeko, et al. "A Successful Second Unrelated BMT (UBMT) From a Different Unrelated Donor to Treat ALL That Relapsed After the Initial UBMT." American Journal of Hematology, vol. 71, no. 1, 2002, pp. 37-40.
Uehara T, Nakaseko C, Yokota A, et al. A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. Am J Hematol. 2002;71(1):37-40.
Uehara, T., Nakaseko, C., Yokota, A., Saito, Y., & Nishimura, M. (2002). A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. American Journal of Hematology, 71(1), 37-40.
Uehara T, et al. A Successful Second Unrelated BMT (UBMT) From a Different Unrelated Donor to Treat ALL That Relapsed After the Initial UBMT. Am J Hematol. 2002;71(1):37-40. PubMed PMID: 12221672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. AU - Uehara,Taeko, AU - Nakaseko,Chiaki, AU - Yokota,Akira, AU - Saito,Yasushi, AU - Nishimura,Miki, PY - 2002/9/11/pubmed PY - 2002/10/9/medline PY - 2002/9/11/entrez SP - 37 EP - 40 JF - American journal of hematology JO - Am J Hematol VL - 71 IS - 1 N2 - A 26-year-old male with acute lymphoblastic leukemia (ALL) in its second complete remission received an unrelated bone marrow transplantation (UBMT) following cyclophosphamide plus total body irradiation conditioning. The patient relapsed 7 months after the BMT. He received a second UBMT from a different donor 15 months after the initial UBMT. Conditioning for the second UBMT consisted of busulphan, melphalan, and anti-thymocyte globulin. The regimen was well tolerated, and engraftment was achieved. Both acute and chronic graft-versus-host diseases occurred but were successfully controlled with immunosuppressive drugs. He is alive and disease-free 29 months after the second UBMT. This is the first report of a successful second UBMT for ALL that had relapsed after the first UBMT and for which a different donor was used. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/12221672/A_successful_second_unrelated_BMT__UBMT__from_a_different_unrelated_donor_to_treat_ALL_that_relapsed_after_the_initial_UBMT_ L2 - https://doi.org/10.1002/ajh.10166 DB - PRIME DP - Unbound Medicine ER -