Tags

Type your tag names separated by a space and hit enter

Age-related total gray matter and white matter changes in normal adult brain. Part II: quantitative magnetization transfer ratio histogram analysis.

Abstract

BACKGROUND AND PURPOSE

The magnetization transfer ratio (MTR) is a sensitive and quantitative identifier of underlying structural changes in the brain. We quantitatively evaluated age- and sex-related MTR changes in global gray matter (GM) and global white matter (WM) in healthy adults.

METHODS

Fifty-two healthy volunteers (21 men, 31 women) aged 20-86 years underwent dual-echo fast spin-echo and magnetization transfer imaging performed with and then without a saturation pulse. GM and WM were distinguished by using a computer-assisted semiautomated segmentation technique. MTR histograms were generated for each segmented tissue in each subject and compared among age and sex groups.

RESULTS

The mean, median, first quartile, and peak height of the MTR histogram were significantly lower in the older group (> or =50 years) than those in the younger group (<50 years) for both GM and WM. The age dependency of these values can be expressed in a quadratic fashion over the entire span of adulthood. The MTRs started to decline only after the age of approximately 40 years in both tissues. No statistically significant differences in MTR histogram measurements between the sexes were observed.

CONCLUSION

The different MTR values for both GM and WM in the two age groups suggest that notable microscopic changes occur in GM and WM with advancing age, yet no significant sex-related variations in MTR measurements were found in these neurologically healthy adults. Such normative data based on the inherent contrast in MTRs are essential in studies of specific disorders of aging, and they may have implications for our understanding of the gross structural changes in both GM and WM in the aging brain.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA.

    , , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Brain
    Female
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Sex Factors

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12223374

    Citation

    Ge, Yulin, et al. "Age-related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part II: Quantitative Magnetization Transfer Ratio Histogram Analysis." AJNR. American Journal of Neuroradiology, vol. 23, no. 8, 2002, pp. 1334-41.
    Ge Y, Grossman RI, Babb JS, et al. Age-related total gray matter and white matter changes in normal adult brain. Part II: quantitative magnetization transfer ratio histogram analysis. AJNR Am J Neuroradiol. 2002;23(8):1334-41.
    Ge, Y., Grossman, R. I., Babb, J. S., Rabin, M. L., Mannon, L. J., & Kolson, D. L. (2002). Age-related total gray matter and white matter changes in normal adult brain. Part II: quantitative magnetization transfer ratio histogram analysis. AJNR. American Journal of Neuroradiology, 23(8), pp. 1334-41.
    Ge Y, et al. Age-related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part II: Quantitative Magnetization Transfer Ratio Histogram Analysis. AJNR Am J Neuroradiol. 2002;23(8):1334-41. PubMed PMID: 12223374.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Age-related total gray matter and white matter changes in normal adult brain. Part II: quantitative magnetization transfer ratio histogram analysis. AU - Ge,Yulin, AU - Grossman,Robert I, AU - Babb,James S, AU - Rabin,Marcie L, AU - Mannon,Lois J, AU - Kolson,Dennis L, PY - 2002/9/12/pubmed PY - 2003/1/22/medline PY - 2002/9/12/entrez SP - 1334 EP - 41 JF - AJNR. American journal of neuroradiology JO - AJNR Am J Neuroradiol VL - 23 IS - 8 N2 - BACKGROUND AND PURPOSE: The magnetization transfer ratio (MTR) is a sensitive and quantitative identifier of underlying structural changes in the brain. We quantitatively evaluated age- and sex-related MTR changes in global gray matter (GM) and global white matter (WM) in healthy adults. METHODS: Fifty-two healthy volunteers (21 men, 31 women) aged 20-86 years underwent dual-echo fast spin-echo and magnetization transfer imaging performed with and then without a saturation pulse. GM and WM were distinguished by using a computer-assisted semiautomated segmentation technique. MTR histograms were generated for each segmented tissue in each subject and compared among age and sex groups. RESULTS: The mean, median, first quartile, and peak height of the MTR histogram were significantly lower in the older group (> or =50 years) than those in the younger group (<50 years) for both GM and WM. The age dependency of these values can be expressed in a quadratic fashion over the entire span of adulthood. The MTRs started to decline only after the age of approximately 40 years in both tissues. No statistically significant differences in MTR histogram measurements between the sexes were observed. CONCLUSION: The different MTR values for both GM and WM in the two age groups suggest that notable microscopic changes occur in GM and WM with advancing age, yet no significant sex-related variations in MTR measurements were found in these neurologically healthy adults. Such normative data based on the inherent contrast in MTRs are essential in studies of specific disorders of aging, and they may have implications for our understanding of the gross structural changes in both GM and WM in the aging brain. SN - 0195-6108 UR - https://www.unboundmedicine.com/medline/citation/12223374/Age_related_total_gray_matter_and_white_matter_changes_in_normal_adult_brain__Part_II:_quantitative_magnetization_transfer_ratio_histogram_analysis_ L2 - http://www.ajnr.org/cgi/pmidlookup?view=long&amp;pmid=12223374 DB - PRIME DP - Unbound Medicine ER -