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[Importance of determining serologic markers in patients with celiac disease].
Cas Lek Cesk 2002; 141(15):487-90CL

Abstract

BACKGROUND

Coeliac disease is presently considered to be an autoimmune disorder. Basis for the diagnosis is the invasive histochemical examination of the intestinal biopsy. Pathologic changes are classified into three grades according to the villous atrophy. Due to the autoimmune process, the patients serum levels of the specific and nonspecific antibodies, more which easily accessible to investigation, are increase.

METHODS AND RESULTS

One hundred thirty six probands (32 with coeliakia, 72 with other gastrointestinal disorders and 32 healthy ones) were included into the study. The antiendomysial, antireticular and antigliadin antibodies were examined. Results were compared with the histological finding in the gut sample. The highest sensitivity was found for antigliadin IgA antibodies (81%) and antiendomysial antibodies (75%). High specificity of the reaction in healthy subjects as well as in those with other gastrointestinal disorders (up to 100%), was found for antiendomysial and antireticular antibodies.

CONCLUSIONS

The most appropriate screening test the diagnosis of coeliac disease, appears to be the examination of the antigliadin antibodies of the class IgA and that of antiendomysial antibodies. On the basis of serology, today's high rate of underdiagnosing the disease can be prevented. However, the tests cannot differentiate between different degrees of the histological damage of the gut.

Authors+Show Affiliations

Interné oddelenie Zeleznicnej nemocnice s poliklinikou, Klinické oddelenie Ustavu preventívnej a klinickej medicíny, Bratislava. ilavska@lipha.skNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

slo

PubMed ID

12226916

Citation

Ilavská, A, et al. "[Importance of Determining Serologic Markers in Patients With Celiac Disease]." Casopis Lekaru Ceskych, vol. 141, no. 15, 2002, pp. 487-90.
Ilavská A, Paulovicová E, Mikulecký M. [Importance of determining serologic markers in patients with celiac disease]. Cas Lek Cesk. 2002;141(15):487-90.
Ilavská, A., Paulovicová, E., & Mikulecký, M. (2002). [Importance of determining serologic markers in patients with celiac disease]. Casopis Lekaru Ceskych, 141(15), pp. 487-90.
Ilavská A, Paulovicová E, Mikulecký M. [Importance of Determining Serologic Markers in Patients With Celiac Disease]. Cas Lek Cesk. 2002 Aug 2;141(15):487-90. PubMed PMID: 12226916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Importance of determining serologic markers in patients with celiac disease]. AU - Ilavská,A, AU - Paulovicová,E, AU - Mikulecký,M, PY - 2002/9/14/pubmed PY - 2002/10/3/medline PY - 2002/9/14/entrez SP - 487 EP - 90 JF - Casopis lekaru ceskych JO - Cas. Lek. Cesk. VL - 141 IS - 15 N2 - BACKGROUND: Coeliac disease is presently considered to be an autoimmune disorder. Basis for the diagnosis is the invasive histochemical examination of the intestinal biopsy. Pathologic changes are classified into three grades according to the villous atrophy. Due to the autoimmune process, the patients serum levels of the specific and nonspecific antibodies, more which easily accessible to investigation, are increase. METHODS AND RESULTS: One hundred thirty six probands (32 with coeliakia, 72 with other gastrointestinal disorders and 32 healthy ones) were included into the study. The antiendomysial, antireticular and antigliadin antibodies were examined. Results were compared with the histological finding in the gut sample. The highest sensitivity was found for antigliadin IgA antibodies (81%) and antiendomysial antibodies (75%). High specificity of the reaction in healthy subjects as well as in those with other gastrointestinal disorders (up to 100%), was found for antiendomysial and antireticular antibodies. CONCLUSIONS: The most appropriate screening test the diagnosis of coeliac disease, appears to be the examination of the antigliadin antibodies of the class IgA and that of antiendomysial antibodies. On the basis of serology, today's high rate of underdiagnosing the disease can be prevented. However, the tests cannot differentiate between different degrees of the histological damage of the gut. SN - 0008-7335 UR - https://www.unboundmedicine.com/medline/citation/12226916/[Importance_of_determining_serologic_markers_in_patients_with_celiac_disease]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -