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[A comparative study of membrane destructive action of dibucaine HCl and bupivacaine HCl].
Masui. 2002 Aug; 51(8):851-6.M

Abstract

Membrane destructive action of dibucaine HCl and bupivacaine HCl was examined in vitro using red blood cells. The EC50 value (local anesthetic concentration needed to destroy half of red blood cells in vitro) of each local anesthetic was determined at pH 5.0, 6.0 and 7.0 to obtain a pH-EC50 curve. The pH change of each commercially available local anesthetic solution (0.3% dibucaine HCl and 0.5% bupivacaine HCl) was also determined with the dilution by cerebrospinal fluid to yield a pH-concentration curve. The EC50 values of dibucaine HCl were 0.17%, 0.18% and 0.13% at pH 5.0, 6.0 and 7.0, respectively. The EC50 values of bupivacaine HCl were 1.36% and 1.36% at pH 5.0 and 6.0, respectively. The EC50 value of bupivacaine HCl at pH 7.0 could not be measured for the low solubility in water at pH 7.0. The pH-EC50 curve of dibucaine HCl intersected the pH-concentration curve, although the pH-EC50 curve of bupivacaine located in the right side (higher concentration) for the pH-concentration curve of bupivacaine HCl, which implies clinical level of dibucaine HCl may produce membrane destruction action and low possibility of membrane destruction with clinical level of bupivacaine HCl.

Authors+Show Affiliations

Department of Anesthesia, Miyazaki Shigun-Ishikai Hospital, Miyazaki 880-0834.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

jpn

PubMed ID

12229132

Citation

Katsuki, Hiroshi, et al. "[A Comparative Study of Membrane Destructive Action of Dibucaine HCl and Bupivacaine HCl]." Masui. the Japanese Journal of Anesthesiology, vol. 51, no. 8, 2002, pp. 851-6.
Katsuki H, Komatsu M, Egawa H, et al. [A comparative study of membrane destructive action of dibucaine HCl and bupivacaine HCl]. Masui. 2002;51(8):851-6.
Katsuki, H., Komatsu, M., Egawa, H., Nagata, N., & Takasaki, M. (2002). [A comparative study of membrane destructive action of dibucaine HCl and bupivacaine HCl]. Masui. the Japanese Journal of Anesthesiology, 51(8), 851-6.
Katsuki H, et al. [A Comparative Study of Membrane Destructive Action of Dibucaine HCl and Bupivacaine HCl]. Masui. 2002;51(8):851-6. PubMed PMID: 12229132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A comparative study of membrane destructive action of dibucaine HCl and bupivacaine HCl]. AU - Katsuki,Hiroshi, AU - Komatsu,Miki, AU - Egawa,Hisako, AU - Nagata,Naoto, AU - Takasaki,Mayumi, PY - 2002/9/17/pubmed PY - 2002/11/26/medline PY - 2002/9/17/entrez SP - 851 EP - 6 JF - Masui. The Japanese journal of anesthesiology JO - Masui VL - 51 IS - 8 N2 - Membrane destructive action of dibucaine HCl and bupivacaine HCl was examined in vitro using red blood cells. The EC50 value (local anesthetic concentration needed to destroy half of red blood cells in vitro) of each local anesthetic was determined at pH 5.0, 6.0 and 7.0 to obtain a pH-EC50 curve. The pH change of each commercially available local anesthetic solution (0.3% dibucaine HCl and 0.5% bupivacaine HCl) was also determined with the dilution by cerebrospinal fluid to yield a pH-concentration curve. The EC50 values of dibucaine HCl were 0.17%, 0.18% and 0.13% at pH 5.0, 6.0 and 7.0, respectively. The EC50 values of bupivacaine HCl were 1.36% and 1.36% at pH 5.0 and 6.0, respectively. The EC50 value of bupivacaine HCl at pH 7.0 could not be measured for the low solubility in water at pH 7.0. The pH-EC50 curve of dibucaine HCl intersected the pH-concentration curve, although the pH-EC50 curve of bupivacaine located in the right side (higher concentration) for the pH-concentration curve of bupivacaine HCl, which implies clinical level of dibucaine HCl may produce membrane destruction action and low possibility of membrane destruction with clinical level of bupivacaine HCl. SN - 0021-4892 UR - https://www.unboundmedicine.com/medline/citation/12229132/[A_comparative_study_of_membrane_destructive_action_of_dibucaine_HCl_and_bupivacaine_HCl]_ L2 - https://www.medicalonline.jp/meteo_linkout.php?issn=0021-4892&volume=51&issue=8&spage=851 DB - PRIME DP - Unbound Medicine ER -