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Effects of American ginseng berry extract on blood glucose levels in ob/ob mice.
Am J Chin Med. 2002; 30(2-3):187-94.AJ

Abstract

In this study, we evaluated antihyperglycemic effects of American ginseng berry extract in diabetic ob/ob mice. Animals received daily intraperitoneal (IP) injections of the extract 150 mg/kg for 12 days. On days 5 and 12, the extract-treated ob/ob mice had significantly lower fasting blood glucose levels compared to day 0 (both p < 0.05). Glucose tolerance improved significantly, which was shown by overall glucose excursion, calculated as area under the curve (AUC) during the two-hour IP glucose tolerance test. The AUC decreased by 31.8% on day 12 compared to day 0 (p < 0.01). In addition, after 12 days of the berry extract treatment, a significant reduction in body weight (p < 0.01 compared to day 0) and a significant increase in body temperature (p < 0.01 compared to day 0) was noticeable. Our results support in vivo antihyperglycemic and antiobese activity of American ginseng berry extract that may prove to be of clinical importance in the prevention and treatment of Type 2 diabetes.

Authors+Show Affiliations

Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12230007

Citation

Xie, Jing-Tian, et al. "Effects of American Ginseng Berry Extract On Blood Glucose Levels in Ob/ob Mice." The American Journal of Chinese Medicine, vol. 30, no. 2-3, 2002, pp. 187-94.
Xie JT, Aung HH, Wu JA, et al. Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. Am J Chin Med. 2002;30(2-3):187-94.
Xie, J. T., Aung, H. H., Wu, J. A., Attel, A. S., & Yuan, C. S. (2002). Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. The American Journal of Chinese Medicine, 30(2-3), 187-94.
Xie JT, et al. Effects of American Ginseng Berry Extract On Blood Glucose Levels in Ob/ob Mice. Am J Chin Med. 2002;30(2-3):187-94. PubMed PMID: 12230007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. AU - Xie,Jing-Tian, AU - Aung,Han H, AU - Wu,Ji An, AU - Attel,A S, AU - Yuan,Chun-Su, PY - 2002/9/17/pubmed PY - 2003/5/3/medline PY - 2002/9/17/entrez SP - 187 EP - 94 JF - The American journal of Chinese medicine JO - Am. J. Chin. Med. VL - 30 IS - 2-3 N2 - In this study, we evaluated antihyperglycemic effects of American ginseng berry extract in diabetic ob/ob mice. Animals received daily intraperitoneal (IP) injections of the extract 150 mg/kg for 12 days. On days 5 and 12, the extract-treated ob/ob mice had significantly lower fasting blood glucose levels compared to day 0 (both p < 0.05). Glucose tolerance improved significantly, which was shown by overall glucose excursion, calculated as area under the curve (AUC) during the two-hour IP glucose tolerance test. The AUC decreased by 31.8% on day 12 compared to day 0 (p < 0.01). In addition, after 12 days of the berry extract treatment, a significant reduction in body weight (p < 0.01 compared to day 0) and a significant increase in body temperature (p < 0.01 compared to day 0) was noticeable. Our results support in vivo antihyperglycemic and antiobese activity of American ginseng berry extract that may prove to be of clinical importance in the prevention and treatment of Type 2 diabetes. SN - 0192-415X UR - https://www.unboundmedicine.com/medline/citation/12230007/Effects_of_American_ginseng_berry_extract_on_blood_glucose_levels_in_ob/ob_mice_ L2 - https://www.worldscientific.com/doi/full/10.1142/S0192415X02000442?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -