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The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands General Practice Database.
Am J Respir Crit Care Med. 2002 Sep 15; 166(6):827-32.AJ

Abstract

The etiology of allergic disease is not understood, but a decreased exposure to infection may play an important role. There are few published data on the impact of change in microbial exposure during pregnancy on the child's risk of developing allergic disease. Using a birth cohort of 24,690 children, derived from the West Midlands General Practice Research Database, we investigated a number of perinatal exposures on the incidence of asthma, eczema, and hay fever. Our findings suggest that exposure to antibiotics in utero is associated with an increased risk of asthma in a dose-related manner (more than two courses of antibiotics compared with none adjusted hazard ratio [HR] 1.68; 95% confidence interval [CI], 1.51-1.87), and similar associations are present for eczema (adjusted HR 1.17; 95% CI, 1.06-1.29) and hay fever (adjusted HR 1.56; 95% CI, 1.22-2.01). Exposure to a range of infections in utero was also associated with a small increased risk of developing allergic disease. Strong protective effects of older siblings on the incidence of allergy are present within this cohort, but previous pregnancies that did not result in a live birth were not protective. Our findings suggest that exposure to antibiotics and to infections in utero is a potentially important risk factor in the development of allergic disease.

Authors+Show Affiliations

Division of Respiratory Medicine, University of Nottingham, Nottingham, United Kingdom. tricia.mckeever@nottingham.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12231492

Citation

McKeever, Tricia M., et al. "The Importance of Prenatal Exposures On the Development of Allergic Disease: a Birth Cohort Study Using the West Midlands General Practice Database." American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 6, 2002, pp. 827-32.
McKeever TM, Lewis SA, Smith C, et al. The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands General Practice Database. Am J Respir Crit Care Med. 2002;166(6):827-32.
McKeever, T. M., Lewis, S. A., Smith, C., & Hubbard, R. (2002). The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands General Practice Database. American Journal of Respiratory and Critical Care Medicine, 166(6), 827-32.
McKeever TM, et al. The Importance of Prenatal Exposures On the Development of Allergic Disease: a Birth Cohort Study Using the West Midlands General Practice Database. Am J Respir Crit Care Med. 2002 Sep 15;166(6):827-32. PubMed PMID: 12231492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands General Practice Database. AU - McKeever,Tricia M, AU - Lewis,Sarah A, AU - Smith,Chris, AU - Hubbard,Richard, PY - 2002/9/17/pubmed PY - 2002/10/12/medline PY - 2002/9/17/entrez SP - 827 EP - 32 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 166 IS - 6 N2 - The etiology of allergic disease is not understood, but a decreased exposure to infection may play an important role. There are few published data on the impact of change in microbial exposure during pregnancy on the child's risk of developing allergic disease. Using a birth cohort of 24,690 children, derived from the West Midlands General Practice Research Database, we investigated a number of perinatal exposures on the incidence of asthma, eczema, and hay fever. Our findings suggest that exposure to antibiotics in utero is associated with an increased risk of asthma in a dose-related manner (more than two courses of antibiotics compared with none adjusted hazard ratio [HR] 1.68; 95% confidence interval [CI], 1.51-1.87), and similar associations are present for eczema (adjusted HR 1.17; 95% CI, 1.06-1.29) and hay fever (adjusted HR 1.56; 95% CI, 1.22-2.01). Exposure to a range of infections in utero was also associated with a small increased risk of developing allergic disease. Strong protective effects of older siblings on the incidence of allergy are present within this cohort, but previous pregnancies that did not result in a live birth were not protective. Our findings suggest that exposure to antibiotics and to infections in utero is a potentially important risk factor in the development of allergic disease. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/12231492/The_importance_of_prenatal_exposures_on_the_development_of_allergic_disease:_a_birth_cohort_study_using_the_West_Midlands_General_Practice_Database_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.200202-158OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -