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hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer.
Clin Cancer Res. 2002 Sep; 8(9):2883-9.CC

Abstract

Activation of telomerase plays a critical role in unlimited proliferation and immortalization of cells. The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase catalytic subunit (hTERT) as a prognostic marker. The expression of hTERT in a large population of 153 patients with stage I non-small cell lung cancer was analyzed using the in situ hybridization technique. We found that diffuse and clear hTERT expression was present in 51 (33%) of 153 patients. Kaplan-Meier analysis showed that hTERT expression was associated with shorter overall survival (P = 0.04), shorter disease-specific survival (P = 0.03), and shorter disease-free survival (P = 0.02). Multivariate analysis confirmed this independent prognostic value of hTERT expression. Our results indicated that hTERT mRNA expression is associated with malignant tumor progression and poor outcome. hTERT may serve as a useful marker to identify patients with poor prognosis and to select patients with early-stage non-small cell lung cancer who might benefit from adjuvant treatment.

Authors+Show Affiliations

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12231532

Citation

Wang, Luo, et al. "HTERT Expression Is a Prognostic Factor of Survival in Patients With Stage I Non-small Cell Lung Cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 8, no. 9, 2002, pp. 2883-9.
Wang L, Soria JC, Kemp BL, et al. HTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer. Clin Cancer Res. 2002;8(9):2883-9.
Wang, L., Soria, J. C., Kemp, B. L., Liu, D. D., Mao, L., & Khuri, F. R. (2002). HTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 8(9), 2883-9.
Wang L, et al. HTERT Expression Is a Prognostic Factor of Survival in Patients With Stage I Non-small Cell Lung Cancer. Clin Cancer Res. 2002;8(9):2883-9. PubMed PMID: 12231532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer. AU - Wang,Luo, AU - Soria,Jean-Charles, AU - Kemp,Bonnie L, AU - Liu,Diane D, AU - Mao,Li, AU - Khuri,Fadlo R, PY - 2002/9/17/pubmed PY - 2002/11/26/medline PY - 2002/9/17/entrez SP - 2883 EP - 9 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 8 IS - 9 N2 - Activation of telomerase plays a critical role in unlimited proliferation and immortalization of cells. The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase catalytic subunit (hTERT) as a prognostic marker. The expression of hTERT in a large population of 153 patients with stage I non-small cell lung cancer was analyzed using the in situ hybridization technique. We found that diffuse and clear hTERT expression was present in 51 (33%) of 153 patients. Kaplan-Meier analysis showed that hTERT expression was associated with shorter overall survival (P = 0.04), shorter disease-specific survival (P = 0.03), and shorter disease-free survival (P = 0.02). Multivariate analysis confirmed this independent prognostic value of hTERT expression. Our results indicated that hTERT mRNA expression is associated with malignant tumor progression and poor outcome. hTERT may serve as a useful marker to identify patients with poor prognosis and to select patients with early-stage non-small cell lung cancer who might benefit from adjuvant treatment. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/12231532/hTERT_expression_is_a_prognostic_factor_of_survival_in_patients_with_stage_I_non_small_cell_lung_cancer_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12231532 DB - PRIME DP - Unbound Medicine ER -