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[Children with fever peaks and bone and joint pain: systemic juvenile idiopathic arthritis or acute lymphoblastic leukemia after all?].
Ned Tijdschr Geneeskd. 2002 Aug 31; 146(35):1613-6.NT

Abstract

In two 3-year-old infants, a girl and a boy, systemic juvenile idiopathic arthritis was suspected because of daily fever peaks, signs of polyarthritis and general malaise. Drug treatment was unsuccessful, and after extensive laboratory investigation acute lymphoblastic leukaemia (ALL) was diagnosed and treated adequately. ALL is the most common malignancy in childhood. About one-third of the patients present with joint or bone pain and fever. In this group of children, it can be difficult to identify ALL because it may mimic the clinical picture of systemic juvenile idiopathic arthritis and because of the possibility of a normal blood count at presentation. ALL should always be considered in the differential diagnosis in children with musculoskeletal pain and fever, even in the face of a normal blood count. In any case, a bone-marrow examination should be done before steroid treatment is given.

Authors+Show Affiliations

Afd. Hematologie en Oncologie, Universitair Medisch Centrum, locatie Wilhelmina Kinderziekenhuis, Postbus 85.090, 3508 AB Utrecht. e.c.roks@wkz.azu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

dut

PubMed ID

12233152

Citation

Koolman, A H., et al. "[Children With Fever Peaks and Bone and Joint Pain: Systemic Juvenile Idiopathic Arthritis or Acute Lymphoblastic Leukemia After All?]." Nederlands Tijdschrift Voor Geneeskunde, vol. 146, no. 35, 2002, pp. 1613-6.
Koolman AH, Kamphuis SS, Weggelaar NM, et al. [Children with fever peaks and bone and joint pain: systemic juvenile idiopathic arthritis or acute lymphoblastic leukemia after all?]. Ned Tijdschr Geneeskd. 2002;146(35):1613-6.
Koolman, A. H., Kamphuis, S. S., Weggelaar, N. M., van den Bos, C., Wulffraat, N. M., & Révész, T. (2002). [Children with fever peaks and bone and joint pain: systemic juvenile idiopathic arthritis or acute lymphoblastic leukemia after all?]. Nederlands Tijdschrift Voor Geneeskunde, 146(35), 1613-6.
Koolman AH, et al. [Children With Fever Peaks and Bone and Joint Pain: Systemic Juvenile Idiopathic Arthritis or Acute Lymphoblastic Leukemia After All?]. Ned Tijdschr Geneeskd. 2002 Aug 31;146(35):1613-6. PubMed PMID: 12233152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Children with fever peaks and bone and joint pain: systemic juvenile idiopathic arthritis or acute lymphoblastic leukemia after all?]. AU - Koolman,A H, AU - Kamphuis,S S M, AU - Weggelaar,N M, AU - van den Bos,C, AU - Wulffraat,N M, AU - Révész,T, PY - 2002/9/18/pubmed PY - 2002/11/30/medline PY - 2002/9/18/entrez SP - 1613 EP - 6 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 146 IS - 35 N2 - In two 3-year-old infants, a girl and a boy, systemic juvenile idiopathic arthritis was suspected because of daily fever peaks, signs of polyarthritis and general malaise. Drug treatment was unsuccessful, and after extensive laboratory investigation acute lymphoblastic leukaemia (ALL) was diagnosed and treated adequately. ALL is the most common malignancy in childhood. About one-third of the patients present with joint or bone pain and fever. In this group of children, it can be difficult to identify ALL because it may mimic the clinical picture of systemic juvenile idiopathic arthritis and because of the possibility of a normal blood count at presentation. ALL should always be considered in the differential diagnosis in children with musculoskeletal pain and fever, even in the face of a normal blood count. In any case, a bone-marrow examination should be done before steroid treatment is given. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/12233152/[Children_with_fever_peaks_and_bone_and_joint_pain:_systemic_juvenile_idiopathic_arthritis_or_acute_lymphoblastic_leukemia_after_all]_ L2 - https://www.diseaseinfosearch.org/result/594 DB - PRIME DP - Unbound Medicine ER -